Ma Changguo, Yu An, He Tingyan, Qian Yulin, Hu Min
Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases, Kunming University, Kunming 650214, China.
Int J Mol Sci. 2025 Jun 30;26(13):6320. doi: 10.3390/ijms26136320.
Characterized by insufficient blood supply leading to tissue hypoxia and damage, ischemia is the underlying cause of major conditions such as ischemic stroke, myocardial infarction, and peripheral artery disease. Stem cell therapy, as a regenerative strategy, demonstrates significant potential in restoring tissue blood flow and organ function in ischemic environments. This review systematically explores the latest advances in stem cell therapy for ischemic diseases, focusing on different cell types and their mechanisms of action, including direct differentiation, paracrine signaling, immunomodulation, and microenvironment regulation. Furthermore, it highlights innovations in gene editing and bioengineering technologies that enhance cell delivery, targeting, and therapeutic efficacy. Simultaneously, this article discusses the challenges faced, advances in cell tracking and delivery, and future research directions, aiming to provide insights for the development of more effective and personalized treatment strategies.
缺血的特征是血液供应不足导致组织缺氧和损伤，它是缺血性中风、心肌梗死和外周动脉疾病等主要病症的根本原因。干细胞疗法作为一种再生策略，在恢复缺血环境中的组织血流和器官功能方面显示出巨大潜力。本综述系统地探讨了缺血性疾病干细胞疗法的最新进展，重点关注不同细胞类型及其作用机制，包括直接分化、旁分泌信号传导、免疫调节和微环境调节。此外，它还强调了基因编辑和生物工程技术的创新，这些创新增强了细胞递送、靶向性和治疗效果。同时，本文讨论了面临的挑战、细胞追踪和递送方面的进展以及未来的研究方向，旨在为开发更有效和个性化的治疗策略提供见解。
