Sun Zhuo, Cięszczyk Paweł, Bojarczuk Aleksandra
College of Physical Education, Chengdu Normal University, Chengdu 611130, China.
Faculty of Physical Culture, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland.
Int J Mol Sci. 2025 Jun 30;26(13):6340. doi: 10.3390/ijms26136340.
Anterior cruciate ligament (ACL) injury (ACLI) is a prevalent sports injury. Genetic factors play a crucial role in determining the risk of ACLI. This systematic review aimed to identify the association between the rs13946 polymorphism and susceptibility to ACLI. Methods: Searches were performed in PubMed Central, Web of Science, EBSCOhost, Scopus, and CNKI. The Newcastle-Ottawa Scale (NOS) was used to assess potential bias, and data from the included studies were analyzed using RevMan 5.4. The odds ratio (OR) and 95% confidence intervals (95% CI) were calculated to determine the strength of the association between rs13946 and the risk of anterior cruciate ligament injury. A value < 0.05 was considered statistically significant. Seven studies met the inclusion criteria for screening the association between rs13946 and ACL injury and were included in this meta-analysis. The meta-analysis revealed no significant heterogeneity across five genetic models. Statistically significant findings were observed in the recessive (OR = 1.29, 95% CI [1.06, 1.58], = 0.01) and allele models (OR = 0.85, 95% CI [0.73, 1.00], = 0.04). The TT genotype or T allele of rs13946 showed a distinct susceptibility to ACLI under the recessive model, particularly in Caucasians. This study supports the association between rs13946 and the risk of ACLI, particularly in Caucasians. More specifically, the C/- genotype of rs13946 provides protection against ACLI in Caucasians. Further research with larger sample sizes and well-balanced gender-specific cohorts is necessary to validate this association and strengthen our findings.
前交叉韧带（ACL）损伤（ACLI）是一种常见的运动损伤。遗传因素在决定ACLI风险方面起着关键作用。本系统评价旨在确定rs13946多态性与ACLI易感性之间的关联。方法：在PubMed Central、Web of Science、EBSCOhost、Scopus和中国知网进行检索。采用纽卡斯尔-渥太华量表（NOS）评估潜在偏倚，并使用RevMan 5.4对纳入研究的数据进行分析。计算比值比（OR）和95%置信区间（95%CI）以确定rs13946与前交叉韧带损伤风险之间关联的强度。P值<0.05被认为具有统计学意义。七项研究符合筛选rs13946与ACL损伤之间关联的纳入标准，并被纳入本荟萃分析。荟萃分析显示，在五种遗传模型中均无显著异质性。在隐性模型（OR = 1.29，95%CI [1.06, 1.58]，P = 0.01）和等位基因模型（OR = 0.85，95%CI [0.73, 1.00]，P = 0.04）中观察到具有统计学意义的结果。在隐性模型下，rs13946的TT基因型或T等位基因显示出对ACLI的明显易感性，尤其是在白种人中。本研究支持rs13946与ACLI风险之间的关联，尤其是在白种人中。更具体地说，rs13946的C/-基因型为白种人提供了对ACLI的保护作用。需要进行更大样本量和性别均衡队列的进一步研究，以验证这种关联并加强我们的研究结果。
