Pecorelli Lisa, Klein Kerstin
Department of Rheumatology and Immunology, Inselspital, Bern University Hospital, University of Bern, 3008 Bern, Switzerland.
Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland.
Int J Mol Sci. 2025 Jul 2;26(13):6367. doi: 10.3390/ijms26136367.
Sjögren's disease is multi-system autoimmune disease characterized by dryness of mucosal surfaces, fatigue, and pain. Heterogeneity among patients is a major obstacle for timely diagnosis, management of patients, and clinical trial design. Strategies for patient stratification are therefore desperately needed. In this review, we aimed to summarize current stratification approaches. Two major approaches for patient stratification are currently used. The first one is based on patient-reported symptoms and the subsequent analysis of the clinical and biological characteristics defining the identified clusters. The second strategy is based on the molecular stratification of patients, followed by the analysis of clinical characteristics along with other biological data. The combination of different approaches holds great potential to improve the recognition of patient subgroups and the development of tailored therapies. The current literature suggests that three to four subgroups of patients with SjD exist. Whether these subgroups represent disease stages or disease endotypes is still a matter of debate and will be a topic of future research.
干燥综合征是一种多系统自身免疫性疾病，其特征为黏膜表面干燥、疲劳和疼痛。患者之间的异质性是及时诊断、患者管理和临床试验设计的主要障碍。因此，迫切需要患者分层策略。在本综述中，我们旨在总结当前的分层方法。目前使用的患者分层主要有两种方法。第一种基于患者报告的症状，随后分析定义已识别集群的临床和生物学特征。第二种策略基于患者的分子分层，随后分析临床特征以及其他生物学数据。不同方法的结合在改善对患者亚组的识别和定制疗法的开发方面具有巨大潜力。当前文献表明，干燥综合征患者存在三到四个亚组。这些亚组是代表疾病阶段还是疾病内型仍存在争议，将是未来研究的一个主题。
