[20-甲基胆蒽诱导小鼠肿瘤恶性程度的比较分析]
[Comparative analysis of the malignancy of tumors in mice induced by 20-methylcholanthrene].
作者信息
Viksler V Kh, Iaroslavtseva O A, Lavroskiĭ V A
出版信息
Eksp Onkol. 1985;7(5):21-4.
PMID:4065015
Abstract
Malignancy of 13 cell cultures cultivated in vitro was studied. 11 cultures were induced by subcutaneous injection of 20-methylcholanthrene to 3 lines of mice. The malignancy was studied by transplantability, growth rate and metastasis formation after subcutaneous injection of a various cell number into normal and sublethally irradiated syngenic mice. A convenient model for studying the significance of certain immunological properties of tumour cells in determination of the malignancy was obtained.
摘要
对13种体外培养的细胞培养物的恶性肿瘤进行了研究。11种培养物是通过向3系小鼠皮下注射20-甲基胆蒽诱导产生的。通过将不同数量的细胞皮下注射到正常和亚致死剂量照射的同基因小鼠体内后，研究其移植性、生长速率和转移形成来评估恶性程度。由此获得了一个用于研究肿瘤细胞某些免疫特性在确定恶性程度中意义的便捷模型。
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