E-17α-（2-[¹²⁵I]碘乙烯基）-19-去甲睾酮：一种用于孕酮受体的γ发射配体的合成。
E-17 alpha-(2-[125I]iodovinyl)-19-nortestosterone: the synthesis of a gamma-emitting ligand for the progesterone receptor.
作者信息
Hochberg R B, Hoyte R M, Rosner W
出版信息
Endocrinology. 1985 Dec;117(6):2550-2. doi: 10.1210/endo-117-6-2550.
PMID:4065046
Abstract
We have synthesized a gamma-emitting steroid, E-17 alpha-(2-[125I]iodovinyl)-19-nortestosterone (E-IVNT), which is a useful ligand for the sensitive and accurate assay of the progesterone receptor. The synthetic scheme is rapid and is performed with readily available materials. This compound, [125I]E-IVNT, is stable and binds with high affinity to the progesterone receptor.
摘要
我们合成了一种发射γ射线的甾体化合物，即E-17α-(2-[125I]碘乙烯基)-19-去甲睾酮（E-IVNT），它是用于灵敏且准确检测孕酮受体的一种有用配体。合成方案快速，且使用的是易于获得的材料。这种化合物，[125I]E-IVNT，性质稳定，能以高亲和力与孕酮受体结合。
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