Suo Jinshan, Shen Xuzhong, Li Dan, Jiang Jing, Qian Yiwen, Wang Xin, Zhang Pei, Wang Minggui, Wang Zhiliang
Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Future Microbiol. 2025 Aug;20(12):769-777. doi: 10.1080/17460913.2025.2530840. Epub 2025 Jul 12.
To evaluate surgical outcomes and prognostic factors related to visual acuity (VA) in endogenous endophthalmitis (EKE).
This retrospective study included patients diagnosed with EKE who underwent pars plana vitrectomy (PPV). Patients were divided into two groups based on the best-corrected VA (BCVA). Eyes with BCVA worse than counting fingers (CF) were classified as having poor vision, while those with BCVA of CF or better were classified as having good vision. Prognostic factors for poor outcomes were identified using least absolute shrinkage and selection operator (LASSO) and logistic regression.
Overall, 64 eyes from 56 patients with EKE were included, of which 51 eyes (43 patients) underwent PPV. At final follow-up, BCVA had improved among patients with PPV. In this subgroup, the mean logarithm of the minimum angle of resolution (logMAR) VA improved from 2.269 ± 0.570 to 2.092 ± 0.713. The VA preservation rate was 86.667%. LASSO and logistic regression showed that three predictors of poor outcomes: poor initial VA, presence of corneal edema, and delayed PPV.
Early PPV is associated with improved VA outcomes in EKE. Poor initial VA, corneal edema, and delayed surgery were significantly associated with worse visual prognosis.
评估内源性眼内炎（EKE）的手术效果及与视力（VA）相关的预后因素。
这项回顾性研究纳入了诊断为EKE并接受玻璃体切割术（PPV）的患者。根据最佳矫正视力（BCVA）将患者分为两组。BCVA低于数指（CF）的眼被分类为视力差，而BCVA为CF或更好的眼被分类为视力好。使用最小绝对收缩和选择算子（LASSO）和逻辑回归确定不良预后的因素。
总体而言，纳入了56例EKE患者的64只眼，其中51只眼（43例患者）接受了PPV。在最后一次随访时，接受PPV的患者BCVA有所改善。在这个亚组中，最小分辨角对数（logMAR）视力的平均值从2.269±0.570提高到2.092±0.713。视力保留率为86.667%。LASSO和逻辑回归显示不良预后的三个预测因素：初始视力差、角膜水肿的存在和PPV延迟。
早期PPV与EKE患者视力改善相关。初始视力差、角膜水肿和手术延迟与较差的视力预后显著相关。
