Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.
Semin Ophthalmol. 2022 Feb 17;37(2):208-214. doi: 10.1080/08820538.2021.1954205. Epub 2021 Jul 19.
To report the clinical features, treatment strategy, and mortality of patients with endogenous panophthalmitis (EP).
Fifteen patients (16 eyes) diagnosed with EP from December 2012 to December 2018 were investigated with a standard protocol at a tertiary medical center of the largest eye center in Northern China. Mortality was followed up.
All participants were Han Chinese. The mean age was 58.3, 62.5% were male, and 93.3% were unilaterally involved. The average number of predisposing factors was 3.0. The top two predisposing factors were diabetes mellitus (DM, 93.3%) and pyogenic liver abscess (PLA, 66.7%). All patients initially presented at an ophthalmic emergency due to severe ocular symptoms. All patients were co-managed by relevant specialists and were admitted to medical or surgical wards instead of the eye center unless the systemic condition was well controlled. Only four eyes were eligible for vitrectomy. The mean follow-up duration was 12.5 months. The mortality rate was 0%. The predominant causative organism was (80.0%), and there were no positive fungal cases.
EP is a rare, life-threatening disease. DM and PLA could predispose its development. The predominant causative organism was . The interdisciplinary cooperation system of the management of EP may reduce the mortality rate. :EP: endogenous panophthalmitis; EE: endogenous endophthalmitis; DM: diabetes mellitus; PLA: pyogenic liver abscess; ACI: acute cerebral infarction; UTI: urinary tract infection; ICU: intensive care unit; VA: visual acuity; LP: light perception; HM: hand motion; NLP: no light perception; ; CT: computed tomography; MRI: magnetic resonance imaging; CRP: C-reactive protein; PCT: procalcitonin; FBG: fasting blood glucose; WBC: white blood cell; NEUT: neutrophil proportion; BDG: 1,3-β-D-glucan; GM: galactomannan; IVI: intravitreal injection; PPV: pars plana vitrectomy; ILAS: invasive liver abscess syndrome; cps: capsular polysaccharide; CSF: cerebrospinal fluid; SD: standard deviation.
报告内源性全眼球炎（EP）患者的临床特征、治疗策略和死亡率。
在华北最大眼科中心的一家三级医疗中心，按照标准方案对 2012 年 12 月至 2018 年期间诊断为 EP 的 15 名患者（16 只眼）进行了调查。对死亡率进行了随访。
所有参与者均为汉族人。平均年龄为 58.3 岁，62.5%为男性，93.3%为单侧受累。平均诱发因素数为 3.0。前两个诱发因素是糖尿病（DM，93.3%）和化脓性肝脓肿（PLA，66.7%）。所有患者最初因严重眼部症状就诊于眼科急诊。所有患者均由相关专家共同管理，并被收治于内科或外科病房，除非全身情况得到良好控制。仅有 4 只眼适合玻璃体切除术。平均随访时间为 12.5 个月。死亡率为 0%。主要病原体为 （80.0%），无阳性真菌病例。
EP 是一种罕见的、危及生命的疾病。DM 和 PLA 可能会引发其发生。主要病原体为 。EP 管理的跨学科合作系统可能降低死亡率。
