Prognostic value of Naples prognostic score for locally advanced gastric cancer after neoadjuvant chemoimmunotherapy.

BACKGROUND

The parameters of the Naples prognostic score (NPS) include albumin, total cholesterol, neutrophil-lymphocyte ratio, and lymphocyte-monocyte ratio. This study aimed to investigate the prognostic value of preoperative NPS in locally advanced gastric cancer(LAGC) patients underwent radical resection after neoadjuvant chemoimmunotherapy (NCIT).

RESEARCH DESIGN AND METHODS

The NPS was calculated and patients were then divided into two groups according to their NPS values as follows: NPS = 0-2 (group 1), NPS = 3-4 (group 2). Univariate and multivariate Cox analysis were used to identify independent prognostic factors associated with overall survival (OS), and time-dependent receiver operating characteristic (t-ROC) curves were carried to evaluate the discriminatory capacity of the prognostic scoring systems.

RESULTS

A total of 117 patients were included in this study. The 1- and 2-year OS rates in group 1 were 100.0% and 95.7%, group 2 exhibited rates of 95.7% and 84.4%. Multivariate cox analysis demonstrated that NPS was an independent prognostic factor of OS ( = 0.009). Furthermore, NPS exhibited better prognostic performance in the prediction of OS than additional prognostic scoring systems.

CONCLUSIONS

NPS is a significant prognostic indicator and can be a reliable predictor of survival in LAGC patients underwent radical resection after NCIT.