炎症和营养状况对晚期卵巢癌长期预后的影响

The Influence of Inflammatory and Nutritional Status on the Long-Term Outcomes in Advanced Stage Ovarian Cancer.

作者信息

Bacalbasa Nicolae, Petrea Sorin, Gaspar Bogdan, Pop Lucian, Varlas Valentin, Hasegan Adrian, Gorecki Gabriel, Martac Cristina, Stoian Marilena, Zgura Anca, Balescu Irina

机构信息

Department of Visceral Surgery, Center of Excellence in Translational Medicine "Fundeni" Clinical Institute, 022328 Bucharest, Romania.

Department of Surgery, "Carol Davila" University of Medicine and Pharmacy, 022328 Bucharest, Romania.

出版信息

Cancers (Basel). 2024 Jul 10;16(14):2504. doi: 10.3390/cancers16142504.

BACKGROUND

Despite improving surgical techniques and achieving more often complete debulking procedures, certain patients with advanced-stage ovarian cancer still have a very poor prognosis. The aim of the current paper is to investigate whether inflammatory and nutritional status can predict the long-term outcomes of ovarian cancer patients.

METHODS

A retrospective analysis of 57 cases diagnosed with advanced-stage ovarian cancer submitted to surgery as first intent therapy was carried out. In all cases, the preoperative status was determined by calculating the CRP/albumin ratio, as well as the Glasgow score, the modified Glasgow score and the prognostic nutritional index.

RESULTS

Patients presenting higher values of the CRP/albumin ratio, with a higher Glasgow score, modified Glasgow score and prognostic nutritional index (PNI), were more frequently associated with incomplete debulking surgery, a higher peritoneal carcinomatosis index and poorer overall survival (20 months versus 9 months for the CRP/albumin ratio = 0.011, 42 versus 27 versus 12 months for the Glasgow score = 0.042, 50 versus 19 versus 12 months for the modified Glasgow score, = 0.001, and 54 months versus 21 months, = 0.011 for the prognostic nutritional index).

CONCLUSIONS

A strong relationship between the nutritional and inflammatory status in advanced-stage ovarian cancer seems to exist.

背景

尽管手术技术不断改进，完全减瘤手术的实施频率也更高，但某些晚期卵巢癌患者的预后仍然很差。本文旨在研究炎症和营养状况是否能预测卵巢癌患者的长期预后。

方法

对57例确诊为晚期卵巢癌并接受初次手术治疗的患者进行回顾性分析。在所有病例中，术前状态通过计算CRP/白蛋白比值以及格拉斯哥评分、改良格拉斯哥评分和预后营养指数来确定。

结果

CRP/白蛋白比值较高、格拉斯哥评分、改良格拉斯哥评分和预后营养指数（PNI）较高的患者，更常与减瘤手术不完全、腹膜癌指数较高和总生存期较差相关（CRP/白蛋白比值为0.011时，生存期分别为20个月和9个月；格拉斯哥评分为0.042时，生存期分别为42个月、27个月和12个月；改良格拉斯哥评分为0.001时，生存期分别为50个月、19个月和12个月；预后营养指数为0.011时，生存期分别为54个月和21个月）。