Sugiura-Ogasawara Mayumi, Suwannarin Neeranuch, Tamada Hazuki, Ebara Takeshi, Ito Yuki, Nakayama Shoji F, Takagi Mai, Saitoh Shinji, Kamijima Michihiro
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Aichi 4678601, Japan.
Japan Environment and Children's Study Programme Office, National Institute for Environmental Studies, Tsukuba 3058506, Japan.
Environ Int. 2025 Aug;202:109663. doi: 10.1016/j.envint.2025.109663. Epub 2025 Jul 4.
Maternal exposure to bisphenols, including bisphenol A (BPA), reportedly results in adverse pregnancy and offspring health outcomes. However, large birth cohort studies on the risk of BPA exposure during pregnancy remain limited. Here, we examined bisphenols' effects on adverse pregnancy and neonatal outcomes using data from the Japan Environment and Children's Study, a nationwide birth cohort study. We selected 4523 women with pregnancies resulting in singleton live births. First-trimester urine concentrations of bisphenols A, F, S, and AF were determined via high-performance liquid chromatography-tandem mass spectrometry. We analyzed the association between BPA exposure and preterm birth, hypertensive disorders of pregnancy, gestational diabetes mellitus, small- and large-for-gestational-age infants, low birth weight, offspring physical and chromosome abnormalities using Bayesian logistic regression analysis after applying the GSimp imputation method for concentrations within the minimum reporting limit. Bisphenol detection rates were generally low (0.0-11.9 % of samples), except for that of BPA (71.5 %), and BPA concentrations were lower than those reported in previous international studies. The estimated BPA daily intake for 86.6 % of the study participants exceeded the European Food Safety Authority's tolerable daily intake (0.0002 µg/kg/day). However, BPA intake was not significantly associated with any outcome. These findings suggest that BPA's current exposure levels do not affect measured pregnancy and neonate outcomes in Japan. Here, although BPA levels reflect only recent exposure, the potential health risks associated with BPA underscore the need for further research to investigate the long-term effects of low-level exposure on maternal and child health.
据报道，孕妇接触双酚类物质，包括双酚A（BPA），会导致不良妊娠和后代健康问题。然而，关于孕期接触双酚A风险的大型出生队列研究仍然有限。在此，我们使用日本环境与儿童研究（一项全国性出生队列研究）的数据，研究了双酚类物质对不良妊娠和新生儿结局的影响。我们选取了4523名单胎活产孕妇。通过高效液相色谱 - 串联质谱法测定孕早期尿液中双酚A、F、S和AF的浓度。在对最低报告限内的浓度应用GSimp插补方法后，我们使用贝叶斯逻辑回归分析，分析了双酚A暴露与早产、妊娠高血压疾病、妊娠期糖尿病、小于胎龄儿和大于胎龄儿、低出生体重、后代身体和染色体异常之间的关联。除双酚A（71.5%）外，双酚类物质的检出率普遍较低（样本的0.0 - 11.9%），且双酚A浓度低于先前国际研究报道的浓度。86.6%的研究参与者的双酚A估计每日摄入量超过了欧洲食品安全局的每日可耐受摄入量（0.0002μg/kg/天）。然而，双酚A摄入量与任何结局均无显著关联。这些发现表明，日本目前的双酚A暴露水平不会影响所测量的妊娠和新生儿结局。在此，虽然双酚A水平仅反映近期暴露情况，但与双酚A相关的潜在健康风险凸显了进一步研究以调查低水平暴露对母婴健康长期影响的必要性。
