Felsenstein Julia, Nelson Katherine M, Shirazi Jasmine, Gleghorn Jason P
Department of Biological Sciences, University of Delaware, Newark, DE, USA.
Department of Biomedical Engineering, University of Delaware, Newark, DE, USA.
J Control Release. 2025 Sep 10;385:114026. doi: 10.1016/j.jconrel.2025.114026. Epub 2025 Jul 10.
The use of nanoparticles (NPs) for therapeutic applications is an expanding field that has more recently begun to focus on pregnancy-related disorders. As the range of medical applications and the types of particles considered for therapeutic use expands, a detailed understanding of the possible risks of exposure during pregnancy is imperative. This review will examine how NP exposure can directly and indirectly affect placental growth and fetal development, as well as its effects on postnatal growth, and summarize the current research on NPs as drug delivery vehicles for treating pregnancy-related disorders. It will also examine how specific particle compositions and surface functionalities may improve particle biocompatibility and, thus, outcomes for the pregnant person and fetus. By assessing the safety of exposure for pregnant individuals and their developing fetuses, and providing insight into how toxicity studies can be made more comprehensive and follow ethical and regulatory guidelines, this review will offer researchers promising approaches for advancing nanotechnology in the maternal-fetal health space while prioritizing patient safety.
将纳米颗粒（NPs）用于治疗应用是一个不断发展的领域，最近已开始关注与妊娠相关的疾病。随着医学应用范围和用于治疗用途的颗粒类型不断扩大，详细了解孕期接触纳米颗粒可能存在的风险势在必行。本综述将探讨纳米颗粒暴露如何直接和间接影响胎盘生长和胎儿发育，以及对产后生长的影响，并总结目前关于纳米颗粒作为治疗妊娠相关疾病的药物递送载体的研究。它还将研究特定的颗粒组成和表面功能如何改善颗粒的生物相容性，从而改善孕妇和胎儿的结局。通过评估孕妇及其发育中的胎儿暴露的安全性，并深入了解如何使毒性研究更全面并遵循伦理和监管指南，本综述将为研究人员提供有前景的方法，以在母婴健康领域推进纳米技术发展，同时将患者安全放在首位。
