Su Sheng-Quan, Xiong Gui-Yuan, Yao Chun-Yan, Liu Xiao-Ling, Xia Yin-Yin, Long Jin-Yun, Li Xiu-Kuan, Wang Liang-Mei, Yi Long, Xu Wu-Wei, Lu Wu-Qiang, Li Qian-Qian, Hu Ting, Liu Hao, Wang Ke-Xue, Luo Peng, Cai Tong-Jian
School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, China; Department of Disease Prevention and Control, Daping Hospital, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University (Third Military Medical University), Chongqing 400042, China.
Department of Epidemiology, College of Preventive Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Ecotoxicol Environ Saf. 2025 Sep 1;302:118623. doi: 10.1016/j.ecoenv.2025.118623. Epub 2025 Jul 12.
T-2 toxin, classified as a mycotoxin, harms immune and cognitive systems. Recently, an increasing number of studies have focused on the neurotoxic effects of T-2 toxin. However, there is still a need for a better understanding of the molecular mechanisms involved. In this study, we aimed to elucidate the protective effect of resveratrol (Res) supplementation against T-2 toxin-induced spatial learning and memory impairment and to investigate the communication mechanisms between the gut and the brain. Mice received a single intraperitoneal dose of T-2 toxin (4 mg/kg) followed by Res (100 mg/kg) administered via the same route. The Morris water maze and novel object recognition tests demonstrated that T-2 toxin had a profound negative impact on spatial learning and memory in mice. However, the administration of Res successfully mitigated the cognitive impairments caused by T-2 toxin and notably enhanced the levels of brain-derived neurotrophic factor (BDNF), synaptophysin I (SYN1), and postsynaptic density protein 95 (PSD-95). Moreover, Res demonstrated a protective effect against T-2 toxin-induced damage to hippocampal tissue. Simultaneously, it played a pivotal role in restoring gut microbiota equilibrium and maintaining the integrity of intestinal tight junctions, effectively curbing both localized and systemic inflammation triggered by T-2 toxin exposure. In conclusion, our findings suggest that resveratrol may alleviate T-2 toxin-induced spatial learning and memory deficits, possibly via gut-brain axis modulation.
T-2毒素属于霉菌毒素，会损害免疫和认知系统。最近，越来越多的研究聚焦于T-2毒素的神经毒性作用。然而，仍需要更好地了解其中涉及的分子机制。在本研究中，我们旨在阐明补充白藜芦醇（Res）对T-2毒素诱导的空间学习和记忆障碍的保护作用，并研究肠道与大脑之间的通讯机制。小鼠腹腔注射单次剂量的T-2毒素（4毫克/千克），随后通过相同途径给予Res（100毫克/千克）。莫里斯水迷宫和新物体识别测试表明，T-2毒素对小鼠的空间学习和记忆有深远的负面影响。然而，给予Res成功减轻了T-2毒素引起的认知障碍，并显著提高了脑源性神经营养因子（BDNF）、突触素I（SYN1）和突触后密度蛋白95（PSD-95）的水平。此外，Res对T-2毒素诱导的海马组织损伤具有保护作用。同时，它在恢复肠道微生物群平衡和维持肠道紧密连接的完整性方面发挥了关键作用，有效抑制了T-2毒素暴露引发的局部和全身炎症。总之，我们的研究结果表明，白藜芦醇可能通过调节肠-脑轴减轻T-2毒素诱导的空间学习和记忆缺陷。
