Comparison of the effects of different isomers of bicuculline infused in the preoptic area on male rat sexual behavior.

Intracerebral infusion of (+) bicuculline methiodide, but not of its (-) isomer, in the preoptic area, stimulated masculine sexual behavior in rat as evidenced by a decrease in the number of intromissions preceding ejaculation and a shortening of the ejaculation latency and postejaculatory interval. Data suggest a role of the GABAergic system in mediating masculine sexual behavior.