有机磷酸酯对大鼠脑组织中胆碱乙酰转移酶活性的抑制作用。
Organophosphate-mediated inhibition of choline acetyltransferase activity in rat brain tissue.
作者信息
Thompson T L, Thomas W E
出版信息
Experientia. 1985 Nov 15;41(11):1437-8. doi: 10.1007/BF01950022.
PMID:4065300
Abstract
Administration of the organophosphate compound soman in rats resulted in an inhibition of choline acetyltransferase activity in almost all brain regions examined. Enzyme activity was inhibited by 20-50% in various brain regions 30 min after soman injection (94-120 micrograms/kg). Enzyme activity in two regions decreased with time to a near zero level by 3 h after injection.
摘要
给大鼠注射有机磷酸酯化合物梭曼后，几乎在所检测的所有脑区中，胆碱乙酰转移酶的活性均受到抑制。梭曼注射（94 - 120微克/千克）30分钟后，各脑区的酶活性被抑制了20% - 50%。注射后3小时，两个脑区的酶活性随时间下降至接近零水平。
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