Xing Wanqun, Shi Huiying, Wu Wencong, Lu Shizhen, Fu Hongxia, Lu Jingjing, Li Shize, Xu Bin
College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China.
College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China.
Dev Comp Immunol. 2025 Aug;169:105420. doi: 10.1016/j.dci.2025.105420. Epub 2025 Jul 12.
Actinobacillus pleuropneumoniae (APP) is a non-spore-forming, Gram-negative facultative, anaerobic bacterium frequently associated with piglet respiratory disease syndrome, which occurs at a notably higher incidence in the winter months and contributes to considerable economic losses to the global pig industry. Following APP infection, porcine lung tissues exhibit a robust inflammatory response characterized by the accumulation of porcine alveolar macrophages (PAMs), suggesting that the magnitude of the immune response elicited by PAMs is a critical determinant of the resolution of APP infection. Furthermore, the β2-adrenergic receptor (ADRB2) is predominantly expressed on the surface of PAMs, although the potential influence of ADRB2 on the immunological reactivity of PAMs post-APP infection remains unclear. Additionally, the regulatory effects of ADRB2 are closely associated with intracellular signaling of the cAMP-PKA pathway, which plays a pivotal role in shaping the immune response of PAMs. The aim of this study was to elucidate the critical regulatory mechanisms underlying the influence of ADRB2 on the antibacterial immunity capacities of PAMs in order to provide a theoretical foundation for the development of ADRB2-based immunomodulatory strategies and offer new insights into the intricate regulatory network governing host antibacterial immunity in response to APP infection.
猪胸膜肺炎放线杆菌（APP）是一种不形成芽孢的革兰氏阴性兼性厌氧菌，常与仔猪呼吸道疾病综合征相关，该疾病在冬季发病率显著更高，给全球养猪业造成相当大的经济损失。APP感染后，猪肺组织表现出强烈的炎症反应，其特征是猪肺泡巨噬细胞（PAM）的积累，这表明PAM引发的免疫反应强度是APP感染消退的关键决定因素。此外，β2肾上腺素能受体（ADRB2）主要在PAM表面表达，尽管ADRB2对APP感染后PAM免疫反应性的潜在影响尚不清楚。此外，ADRB2的调节作用与cAMP-PKA途径的细胞内信号传导密切相关，该途径在塑造PAM的免疫反应中起关键作用。本研究的目的是阐明ADRB2对PAM抗菌免疫能力影响的关键调节机制，为基于ADRB2的免疫调节策略的开发提供理论基础，并为应对APP感染的宿主抗菌免疫复杂调节网络提供新的见解。
