Zaman Fatima, Zhu Xianming, Hunt Joanne H, Rozek Gracie, Eby Yolanda, Hussain Sarah, Desai Niraj M, Florman Sander, Rana Meenakshi M, Friedman-Moraco Rachel, Pereira Marcus R, Mehta Shikha, Stock Peter, Gilbert Alexander, Hand Jonathan, Morris Michele I, Stosor Valentina, Mehta Sapna A, Small Catherine B, Schaenman Joanna, Santos Carlos A Q, Aslam Saima, Wojciechowski David, Malinis Maricar, Haidar Ghady, Odim Jonah, Morsheimer Megan, Segev Dorry L, Redd Andrew D, Durand Christine M, Tobian Aaron A R
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Clin Immunol. 2025 Jul 11;280:110563. doi: 10.1016/j.clim.2025.110563.
Kidney transplantation from donors with HIV has recently become standard clinical practice, but the plasma inflammatory profile is not well characterized. Thirty-two cytokines and chemokines were evaluated among donors with HIV (n = 63) and without HIV (n = 41). Wilcoxon rank sum test was used to compare cytokines between groups. Donors with and without HIV were generally similar in terms of characteristics, except those with HIV had a non-significantly lower kidney donor profile index, reflecting better graft survival, creatinine, and body mass index. Most cytokine and chemokine levels were similar between groups. However, median IL-8 levels were higher (p < 0.0015) in donors without HIV (32.6 pg/mL, IQR = 13.8-394.9) compared to donors with HIV (15.1 pg/mL, IQR = 8.4-35.5). There were no significant correlations between cytokine and chemokine concentrations and CD4 counts or HIV viral load. In summary, inflammatory profiles were similar or lower among donors with HIV compared to donors without HIV supporting the safety of this emerging kidney transplantation practice.
来自感染艾滋病毒供体的肾脏移植最近已成为标准临床实践，但血浆炎症特征尚未得到很好的描述。在感染艾滋病毒的供体（n = 63）和未感染艾滋病毒的供体（n = 41）中评估了32种细胞因子和趋化因子。采用Wilcoxon秩和检验比较两组之间的细胞因子。感染和未感染艾滋病毒的供体在特征方面总体相似，只是感染艾滋病毒的供体肾脏供体特征指数略低，但无统计学意义，这反映出更好的移植物存活率、肌酐水平和体重指数。两组之间大多数细胞因子和趋化因子水平相似。然而，未感染艾滋病毒的供体中白细胞介素-8（IL-8）的中位数水平（32.6 pg/mL，四分位间距IQR = 13.8 - 394.9）高于感染艾滋病毒的供体（15.1 pg/mL，IQR = 8.4 - 35.5）（p < 0.0015）。细胞因子和趋化因子浓度与CD4细胞计数或艾滋病毒病毒载量之间无显著相关性。总之，与未感染艾滋病毒的供体相比，感染艾滋病毒的供体炎症特征相似或更低，这支持了这种新兴肾脏移植实践的安全性。
