Murakonda Swathi P, Balusu Sahasra, Chava Haritha, Murakonda Ajay B, Polneedi Reshmi, Bodduluri Sushanth, Gupta Subash C, Challagundla Kishore B
Sri Rajiv Gandhi College of Dental Sciences & Hospital, Bengaluru, Karnataka, India.
Blue Valley West High School, Overland Park, KS, United States.
Int Rev Cell Mol Biol. 2025;395:23-66. doi: 10.1016/bs.ircmb.2024.12.005. Epub 2025 Jan 22.
The gut microbiota is increasingly being recognized as a key player in the onset and progression of several human diseases, including malignancies. Recent research has shed light on the complex relationships between the gut microbiome and the effectiveness of cancer immunotherapy. Gaining a thorough understanding of how the gut microbiota influences immune responses during cancer treatments is critical for medical advancements. This review aims to delve into the intricate interactions between gut microbiota, the systemic immune system, and cancer immunotherapy. Additionally, as the gut microbiota can contribute to immune-related adverse effects, we explored possible interventions to alleviate these side effects and reviewed microbiota-targeted strategies that could enhance the success of cancer immunotherapies.
