Sato Tomotaka, Nakamura Shin-Ichi, Kadekaru Sho, Nakagawa Mariko, Une Yumi
Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Okayama University of Science, Ehime, Japan.
Gun-ma Safari Park, Gunma, Japan.
J Vet Med Sci. 2025 Sep 1;87(9):995-999. doi: 10.1292/jvms.25-0117. Epub 2025 Jul 14.
This report presents the case of a 22-year-old male squirrel monkey with primary seminal vesicle adenocarcinoma (PSVA). The animal presented with hematuria and emaciation. Pathological autopsy of the seminal vesicle tumor revealed an irregularly shaped, white, solid mass showing ductal/papillary and solid patterns and periodic acid-Schiff-positive mucus in the duct. The vesicle was dilated by blood. Tumor cells showed cytoplasmic eosinophilic granules, and a transition to tumor tissue was observed. Immunohistochemical analysis indicated that all tumor cells were cytokeratin-negative; only ductal/papillary cells were vimentin-positive. Other organs were tumor free. PSVA was diagnosed based on the site of tumor origin and histopathology, similar to PSVA in laboratory rodents. This study reports a case of PSVA in a new-world monkey.
本报告介绍了一例患有原发性精囊腺癌（PSVA）的22岁雄性松鼠猴病例。该动物出现血尿和消瘦症状。精囊肿瘤的病理尸检显示，有一个形状不规则的白色实性肿块，呈现导管/乳头状和实性结构，导管内有过碘酸希夫阳性黏液。精囊因血液而扩张。肿瘤细胞显示有细胞质嗜酸性颗粒，并观察到向肿瘤组织的转变。免疫组织化学分析表明，所有肿瘤细胞细胞角蛋白均为阴性；只有导管/乳头状细胞波形蛋白呈阳性。其他器官未发现肿瘤。根据肿瘤起源部位和组织病理学诊断为PSVA，类似于实验啮齿动物中的PSVA。本研究报告了新大陆猴中一例PSVA病例。
