蛋白酶体衍生肽：区分垃圾与回收物。
Proteasome-derived peptides: separating the trash from the recycling.
作者信息
Brennan Anna, Church Taylor R, Margolis Seth S
机构信息
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Trends Biochem Sci. 2025 Jul 12. doi: 10.1016/j.tibs.2025.06.007.
The proteasome is an essential protein complex in all cells. Proteasomes have two main functions: protein degradation and peptide generation. While proteasome-dependent protein degradation removes proteins and is critical for cellular function, the newly generated proteasome-derived peptides, which range in size and sequence, are emerging as essential cellular effector molecules: they are expressed on MHC-I in the immune system, function as novel modulators of neuronal signaling, are involved in innate immunity and intracellular signaling, and can be metabolized further for important cellular processes. Here, we take a comprehensive look at the mechanics behind proteasome-mediated peptide generation; the function of proteasome-derived peptides in signaling and metabolism relevant to cellular biology, health, and disease; and the techniques enabling these studies.
蛋白酶体是所有细胞中一种重要的蛋白质复合物。蛋白酶体有两个主要功能：蛋白质降解和肽生成。虽然依赖蛋白酶体的蛋白质降解可去除蛋白质并对细胞功能至关重要，但新生成的、大小和序列各异的蛋白酶体衍生肽正成为重要的细胞效应分子：它们在免疫系统中呈递于MHC-I上，作为神经元信号传导的新型调节剂发挥作用，参与先天免疫和细胞内信号传导，并且可进一步代谢以参与重要的细胞过程。在此，我们全面审视蛋白酶体介导的肽生成背后的机制；蛋白酶体衍生肽在与细胞生物学、健康和疾病相关的信号传导和代谢中的功能；以及促成这些研究的技术。
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