Quach Su Sheng, Johnson Nigel, Dudhia Raahib, Puljich Anthony, Ivanovski Sašo, Lee Ryan S B
School of Dentistry, The University of Queensland, Herston, Queensland, Australia.
Oral and Maxillofacial Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
J Clin Periodontol. 2025 Oct;52(10):1419-1429. doi: 10.1111/jcpe.14205. Epub 2025 Jul 13.
To evaluate the effect of deproteinised bovine bone mineral with collagen (DBBM-C) grafting on periodontal healing at the distal aspect of the second molar (D2M) during adjacent third molar extraction.
Forty-two sites in 28 patients were randomly allocated into two groups. The test group (18 sites) received DBBM-C grafting during extraction, whereas the control group (24 sites) received extraction alone. The patients were reviewed 6 months postoperatively, and the D2M and extraction sites were evaluated by both linear and volumetric cone beam computed tomography measurements.
Nine patients dropped out (14 sites) and two patients were excluded (4 sites), leaving a total of 17 patients (24 sites) who were reviewed after 6 months. Both groups showed significant healing when examining the linear measurements (except at the disto-lingual aspect of the second molar) and the defined volumes of interest. There were, however, no significant differences between the groups in the linear or volumetric outcome analyses.
Within the limitations of the study, the use of DBBM-C during third molar extraction did not improve periodontal healing at the D2M. This trial was registered in April 2020 in the Australian New Zealand Clinical Trials Registry under code ACTRN12620000497909 (https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12620000497909).
评估在拔除相邻第三磨牙期间,脱蛋白牛骨矿物质与胶原蛋白(DBBM-C)移植对第二磨牙远中面(D2M)牙周愈合的影响。
28例患者的42个部位被随机分为两组。试验组(18个部位)在拔牙期间接受DBBM-C移植,而对照组(24个部位)仅接受拔牙。术后6个月对患者进行复查,并通过线性和容积锥形束计算机断层扫描测量对D2M和拔牙部位进行评估。
9例患者退出(14个部位),2例患者被排除(4个部位),6个月后共有17例患者(24个部位)接受复查。在检查线性测量(第二磨牙远舌侧除外)和确定的感兴趣体积时,两组均显示出明显的愈合。然而,在组间的线性或容积结果分析中没有显著差异。
在本研究的局限性范围内,在第三磨牙拔除期间使用DBBM-C并不能改善D2M处的牙周愈合。该试验于2020年4月在澳大利亚新西兰临床试验注册中心注册,注册号为ACTRN12620000497909(https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12620000497909)。