Abbas Ali Kareem, Safaei-Ghomi Javad, Moein-Najafabadi Samira
College of Applied Medical Sciences, University of Kerbala, Kerbala, Iraq.
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, P.O. Box 87317-51167, Kashan, I. R. of Iran.
Sci Rep. 2025 Jul 13;15(1):25323. doi: 10.1038/s41598-025-11227-z.
Zirconia nanoparticles modified with L-tryptophan (ZrO₂@L-Try) demonstrate increased biocompatibility and catalytic activity by capitalizing on the bioactive properties of L-tryptophan, a crucial amino acid known for its role in protein synthesis and neurochemical functions. Successful integration of L-tryptophan onto the ZrO matrix is confirmed through characterization methods. This catalytic system was employed effectively in the synthesis of 2 H-indazolo[2,1-b]phthalazine-triones through multi-component, one-pot reactions involving phthalic anhydride, various aldehydes, dimedone, and hydrazinium hydroxide under thermal, solvent-free conditions at 80 °C. Investigations suggest that ZrO@L-Tryptophan exhibits enhanced stability and solubility and holds promise as an innovative platform for drug delivery systems and an efficient catalyst in diverse organic reactions.
用L-色氨酸修饰的氧化锆纳米颗粒（ZrO₂@L-Try）通过利用L-色氨酸的生物活性特性，展现出更高的生物相容性和催化活性。L-色氨酸是一种关键氨基酸，因其在蛋白质合成和神经化学功能中的作用而闻名。通过表征方法证实了L-色氨酸成功整合到ZrO基质上。该催化体系在80°C的热、无溶剂条件下，通过涉及邻苯二甲酸酐、各种醛、二甲基酮和氢氧化肼的多组分一锅法反应，有效地用于合成2H-吲唑并[2,1-b]酞嗪三酮。研究表明，ZrO@L-色氨酸具有更高的稳定性和溶解性，有望成为药物递送系统的创新平台和各种有机反应中的高效催化剂。
