Yue Wenxiu, Shi Zhenan, Yang Luye, Yang Zixuan, Tian Xiaolu, Chen Qiaomin, Cheng Yilin, Zhang Zhiyuan, Xu Zhimin, Han Fuliang
College of Enology, Northwest A&F University, Yangling 712100, Shaanxi, China.
School of Nutrition and Food Sciences, Louisiana State University Agricultural Center, Baton Rouge, Louisiana 70803, United States.
J Agric Food Chem. 2025 Jul 30;73(30):18717-18732. doi: 10.1021/acs.jafc.5c00716. Epub 2025 Jul 14.
The anthocyanins malvidin-3--glucoside (M3G) and malvidin-3,5--diglucoside (M35G) were purified from the grape varieties L. and Foex peels, respectively, and their effects on glycolipid metabolic disorders (GLMDs) were investigated using a mouse model. Mice treated with M3G or M35G showed controlled body weight, preservation of normal histomorphological features and islet size of the pancreas, and amelioration of hyperglycemia and insulin resistance induced by a high-fructose diet. M35G was more effective than M3G in improving insulin sensitivity, lipid homeostasis, and adipocyte hypertrophy. Moreover, M3G and M35G regulated hepatic genes (e.g., ketohexokinase, phosphoenolpyruvate carboxykinase, fatty acid synthase, and carbohydrate response element binding protein-beta) to restrain GLMD development. Furthermore, the inhibition of hepatic inflammation and oxidative stress and the modulation of the abundance of probiotic microbial genera synergistically improved physiological indices and prevented GLMD development.
分别从葡萄品种L.和Foex的果皮中纯化出花青素锦葵色素-3-葡萄糖苷（M3G）和锦葵色素-3,5-二葡萄糖苷（M35G），并使用小鼠模型研究了它们对糖脂代谢紊乱（GLMDs）的影响。用M3G或M35G处理的小鼠体重得到控制，胰腺的正常组织形态学特征和胰岛大小得以保留，由高果糖饮食诱导的高血糖和胰岛素抵抗得到改善。在改善胰岛素敏感性、脂质稳态和脂肪细胞肥大方面，M35G比M3G更有效。此外，M3G和M35G调节肝脏基因（如己酮糖激酶、磷酸烯醇式丙酮酸羧激酶、脂肪酸合酶和碳水化合物反应元件结合蛋白-β）以抑制GLMD的发展。此外，抑制肝脏炎症和氧化应激以及调节益生菌微生物属的丰度协同改善了生理指标并预防了GLMD的发展。
