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再生大鼠肝脏中由6-磷酸葡萄糖体外生成L-乳酸和磷酸甘油的反应速率

Activities of L-lactate and glycerol phosphate production rates in vitro from glucose 6-phosphate in regenerating rat liver.

作者信息

Siverio J M, Torres N V, Meléndez-Hevia E

出版信息

Int J Biochem. 1985;17(9):1015-7. doi: 10.1016/0020-711x(85)90248-4.

DOI:10.1016/0020-711x(85)90248-4
PMID:4065405
Abstract

Activities of L-lactate and glycerol phosphate production in vitro were assayed in regenerating rat liver at different times after partial hepatectomy and were compared with activities of sham operated controls. Results show an oscillatory shift in these activities with smallest values for both L-lactate and glycerol phosphate production rates at 20 hr, these being 80% and 50%, respectively of normal values, and with highest values at 42 hr where these rates were 150% and 125%, respectively, both recovering their original state 60 hr after surgery. From these data it is concluded that in regenerating liver there are changes in the ability of the glycolysis system to produce L-lactate and glycerol phosphate.

摘要

在部分肝切除术后不同时间,对再生大鼠肝脏中L-乳酸和磷酸甘油的体外生成活性进行了测定,并与假手术对照组的活性进行了比较。结果显示,这些活性呈振荡性变化,L-乳酸和磷酸甘油生成率在术后20小时达到最小值,分别为正常值的80%和50%,而在术后42小时达到最大值,此时生成率分别为正常值的150%和125%,术后60小时两者均恢复到原始状态。从这些数据可以得出结论,在再生肝脏中,糖酵解系统产生L-乳酸和磷酸甘油的能力发生了变化。

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