Suppr超能文献

持续使用抗血栓药物对口腔手术出血风险的影响——韩国某大学医院接受治疗的患者群体的回顾性研究

Impact of continued antithrombotic use on bleeding risk in oral surgery- a retrospectively study in a population patients treated in a Korean university hospital.

作者信息

Seo Mi Hyun

机构信息

Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea.

Department of One-Stop Specialty Center, Seoul National University Dental Hospital, Seoul, South Korea.

出版信息

J Dent Sci. 2025 Jul;20(3):1506-1512. doi: 10.1016/j.jds.2024.12.029. Epub 2025 Jan 9.

Abstract

BACKGROUND/PURPOSE: With the growing elderly population and their increasing prevalence of systemic diseases, the use of antithrombotic medications is on the rise. These medications are essential for preventing thromboembolic events in patients with cardiovascular, cerebrovascular diseases. However, their use poses challenges in dental surgeries, where the risk of postoperative bleeding needs to be carefully balanced against the risks of discontinuing antithrombotic therapy. This study aimed to assess whether continuing antithrombotic therapy increases the risk of postoperative bleeding during dental procedures.

MATERIALS AND METHODS

Retrospective analysis was conducted on 118 patients who underwent oral surgeries, including extractions and dental implants. Patients were categorized based on whether they continued or discontinued antithrombotic therapy before the procedure. Data on age, sex, type of antithrombotic agent, and occurrence of delayed bleeding were collected. Multiple regression analysis was used to identify potential risk factors for postoperative bleeding.

RESULTS

Of the 118 patients, 78 continued antithrombotic therapy, while 40 discontinued it. Delayed postoperative bleeding occurred in 10 patients (8.47 %), with no statistically significant difference between those who continued and those who discontinued their medication. The type of antithrombotic agent, interaction between drug cessation and procedure, preoperative platelet count, prothrombin time, and partial thromboplastin time did not significantly affect the incidence of bleeding.

CONCLUSION

Continuing antithrombotic therapy does not significantly increase the risk of postoperative bleeding in patients undergoing oral surgeries. Dental practitioners can consider maintaining antithrombotic therapy during certain procedures, emphasizing the importance of balancing bleeding risks with the potential for thromboembolic events.

摘要

背景/目的:随着老年人口的增加以及他们全身疾病患病率的上升,抗血栓药物的使用正在增加。这些药物对于预防心血管、脑血管疾病患者的血栓栓塞事件至关重要。然而,在牙科手术中使用这些药物存在挑战,因为术后出血风险需要与停止抗血栓治疗的风险仔细权衡。本研究旨在评估继续抗血栓治疗是否会增加牙科手术期间术后出血的风险。

材料与方法

对118例行口腔手术(包括拔牙和牙种植)的患者进行回顾性分析。根据患者在手术前是否继续或停止抗血栓治疗进行分类。收集患者的年龄、性别、抗血栓药物类型和延迟出血的发生情况。采用多元回归分析确定术后出血的潜在危险因素。

结果

118例患者中,78例继续抗血栓治疗,40例停止治疗。10例患者(8.47%)发生术后延迟出血,继续用药组和停药组之间无统计学显著差异。抗血栓药物类型、停药与手术的相互作用、术前血小板计数、凝血酶原时间和活化部分凝血活酶时间对出血发生率无显著影响。

结论

继续抗血栓治疗不会显著增加接受口腔手术患者的术后出血风险。牙科医生在某些手术过程中可以考虑维持抗血栓治疗,强调平衡出血风险与血栓栓塞事件可能性的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f09/12254807/be504b2a251e/gr1.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验