Wiseman M J, Redmond S, House F, Keen H, Viberti G C
Diabetologia. 1985 Oct;28(10):718-21. doi: 10.1007/BF00265017.
Plasma concentrations of glucagon, growth hormone and glucose were measured hourly during an ordinary treatment day in 11 Type 1 (insulin-dependent) diabetic patients with high glomerular filtration rate, 11 Type 1 diabetic patients with normal glomerular filtration rate matched for age, diabetes duration and sex, and five healthy control subjects, simultaneously with the measurement of the glomerular filtration rate using 51Cr EDTA clearance. Plasma glucagon profiles were not statistically distinguishable (p = 0.49) from control values in either group, although they were somewhat lower in the hyperfiltering group. Plasma growth hormone values were higher than control (p = 0.07) in both diabetic groups, but were not different between these two groups (p = 0.94). All indices of glycaemic control (glycosylated haemoglobin, urinary glucose excretion, and plasma glucose concentration) were higher in the hyperfiltering group, although no single index reached statistical significance. No correlations between concentrations of these substances and glomerular filtration rate were found. Elevated plasma concentrations of glucagon and growth hormone do not characterise those diabetic patients with high glomerular filtration rate.
在一个普通治疗日期间，对11名肾小球滤过率高的1型（胰岛素依赖型）糖尿病患者、11名年龄、糖尿病病程和性别相匹配的肾小球滤过率正常的1型糖尿病患者以及5名健康对照者，每小时测量一次胰高血糖素、生长激素和葡萄糖的血浆浓度，同时使用51Cr乙二胺四乙酸清除率测量肾小球滤过率。尽管在超滤过组中血浆胰高血糖素水平略低，但两组的血浆胰高血糖素水平与对照值在统计学上无显著差异（p = 0.49）。两组糖尿病患者的血浆生长激素值均高于对照组（p = 0.07），但两组之间无差异（p = 0.94）。超滤过组的所有血糖控制指标（糖化血红蛋白、尿糖排泄和血浆葡萄糖浓度）均较高，尽管没有一个指标达到统计学显著性。未发现这些物质的浓度与肾小球滤过率之间存在相关性。血浆胰高血糖素和生长激素浓度升高并非肾小球滤过率高的糖尿病患者的特征。
