Lundbaek K
MMW Munch Med Wochenschr. 1977 May 13;119(19):647-54.
In juvenile diabetes there is a renal hypertrophy: glomerular volume and capillary lumen of the individual glomeruli are about twice the size of healthy ones. The hypertrophy is associated with a hyperfunction (increased glomerular filtration and tubular reabsorption). If the diabetes is strictly controlled these changes may regress, which suggests a metabolically induced hypertrophy. Long-standing diabetes is characterized by a phase of intermittent proteinuria which gradually becomes permanent. Diabetic angiopathy is the result of many years of abnormal metabolism, presumably with involvement of the growth hormone and glucose. Whereas microangiopathy is considered specific for diabetes, it is still a matter for discussion whether a diabetic macroangiopathy exists. The results of numerous investigations suggest that it does.
单个肾小球的肾小球体积和毛细血管腔约为健康肾小球的两倍大小。这种肥大与功能亢进（肾小球滤过和肾小管重吸收增加）相关。如果糖尿病得到严格控制，这些变化可能会消退，这表明是代谢诱导的肥大。长期糖尿病的特征是间歇性蛋白尿阶段，逐渐变为持续性。糖尿病性血管病是多年异常代谢的结果，可能涉及生长激素和葡萄糖。虽然微血管病被认为是糖尿病特有的，但糖尿病大血管病是否存在仍存在争议。大量研究结果表明它是存在的。
