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尼美舒利诱发的重症多形红斑：一例报告

Nimesulide-induced Erythema Multiforme Major: A Case Report.

作者信息

Dahal Agnimshwor, Dhungel Prakash, Thapa Astha, Gyawali Jeevan, Shah Amin, Khadgi Pujan, Chauhan Bhim, Karki Prashanna Dip, Shahi Nistha

机构信息

Nepal Intensive Care Research Foundation, Kathmandu, Nepal.

Patan Academy of Health Sciences - School of Medicine (PAHS-SOM), Lalitpur, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2024 Sep;62(277):605-607. doi: 10.31729/jnma.8762. Epub 2024 Sep 30.

DOI:10.31729/jnma.8762
PMID:40655056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11665759/
Abstract

Erythema Multiforme Major (EMM) is a rare hypersensitivity reaction that primarily affects the skin and mucosa, typically self-limiting. This case discusses a patient who developed severe EMM lesions after consuming nimesulide, a non-steroidal anti-inflammatory drug (NSAID), for abdominal discomfort. Patient was admitted to the hospital, the drug was discontinued, and supportive measures such as pain management and fluid replacement were initiated. This case, being the first to identify nimesulide as a possible trigger for EMM, aims to contribute to the growing body of knowledge on this topic. It emphasizes the need for vigilance and swift intervention for unusual drug reactions.

摘要

重症多形红斑（EMM）是一种罕见的超敏反应，主要累及皮肤和黏膜，通常具有自限性。本病例讨论了一名患者，因腹部不适服用非甾体抗炎药（NSAID）尼美舒利后出现了严重的重症多形红斑皮损。患者入院后停用了该药物，并采取了疼痛管理和补液等支持措施。该病例是首例将尼美舒利确定为可能引发重症多形红斑的病例，旨在为该主题不断增长的知识体系做出贡献。它强调了对异常药物反应保持警惕并迅速干预的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bed/11665759/048dee6036df/JNMA-62-277-605-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bed/11665759/a11bd21a6a5d/JNMA-62-277-605-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bed/11665759/2ba79915f137/JNMA-62-277-605-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bed/11665759/6cd7e3d71946/JNMA-62-277-605-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bed/11665759/048dee6036df/JNMA-62-277-605-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bed/11665759/a11bd21a6a5d/JNMA-62-277-605-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bed/11665759/2ba79915f137/JNMA-62-277-605-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bed/11665759/6cd7e3d71946/JNMA-62-277-605-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bed/11665759/048dee6036df/JNMA-62-277-605-g4.jpg

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本文引用的文献

1
Erythema Multiforme: Recognition and Management.多形红斑：识别与管理。
Am Fam Physician. 2019 Jul 15;100(2):82-88.
2
Nimesulide-induced hepatotoxicity: A systematic review and meta-analysis.尼美舒利致肝毒性：系统评价和荟萃分析。
PLoS One. 2019 Jan 24;14(1):e0209264. doi: 10.1371/journal.pone.0209264. eCollection 2019.
3
Stevens-Johnson syndrome and toxic epidermal necrolysis.
Curr Allergy Asthma Rep. 2007 Jul;7(4):243-7. doi: 10.1007/s11882-007-0036-9.
4
Erythema multiforme.多形红斑
Am Fam Physician. 2006 Dec 1;74(11):1883-8.
5
Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study.重症多形红斑、史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的临床模式与病因之间的相关性：一项国际前瞻性研究的结果
Arch Dermatol. 2002 Aug;138(8):1019-24. doi: 10.1001/archderm.138.8.1019.