Jiang Tao, Bin Li, Liu Huiting, Gao Cailiang, Liu Xue
Department of Nuclear Medicine, Hunan University of Medicine General Hospital, Huaihua, Hunan, China.
Department of Nuclear Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
Front Endocrinol (Lausanne). 2025 Jun 27;16:1555841. doi: 10.3389/fendo.2025.1555841. eCollection 2025.
BACKGROUND: Thyroid cancer has increased globally, particularly among young women, highlighting the need for research on its epidemiological characteristics and disease burden in women of child-bearing age. This study aimed to analyze the global and regional burden of thyroid cancer from 1990 to 2021, focusing on women of child-bearing age, and to predict trends up to 2035. METHODS: This study analyzed the global and regional burden of thyroid cancer from 1990 to 2021, focusing on women of child-bearing age, using data from the Global Burden of Disease Study. Key indicators assessed included incidence, mortality, and disability-adjusted life years (DALYs) of thyroid cancer in different regions. Statistical analysis techniques were employed to compare the burden across regions and countries, examining the effects of age, sex, and socio-demographic index (SDI) on disease burden. The Bayesian Age-Period-Cohort model was used to predict the incidence, mortality, and DALYs of thyroid cancer from 2022 to 2035. RESULTS: Globally, in 2021, there were 67,558 new cases of thyroid cancer among women of child-bearing age, with 3,260 deaths and 206,508 DALYs. Compared to 1990, new cases increased by 156.86%, deaths increased by 52.33%, and DALYs increased by 61.72%. The age-standardized incidence rate (ASIR), mortality rate (ASMR), and DALYs rate (ASDR) per 100,000 population were 3.37, 0.16, and 10.38, respectively. The Estimated Annual Percentage Change (EAPC) for ASIR was 1.47, indicating an increasing trend, whereas the EAPCs for ASMR and ASDR were -0.35 and -0.05, showing decreasing trends. The burden of thyroid cancer among patients with women of child-bearing age exhibited a significant age-related trend, peaking in the 45-49 age group. There were significant regional and national variations in thyroid cancer burden, which are closely related to the SDI. By 2035, a notable increase in the incidence, mortality, and DALYs associated with thyroid cancer among women of child-bearing age has been predicted globally. CONCLUSION: Over the past 30 years, thyroid cancer incidence among women has significantly increased globally, with slightly declining mortality and DALYs rates. Significant regional and national variations are closely linked to the SDI. As the population ages and incidence continues to rise, targeted prevention and treatment strategies, particularly in low SDI regions, are crucial to effectively reduce mortality and DALYs.
背景：甲状腺癌在全球范围内呈上升趋势，尤其是在年轻女性中，这凸显了对其在育龄女性中的流行病学特征和疾病负担进行研究的必要性。本研究旨在分析1990年至2021年全球及区域甲状腺癌负担，重点关注育龄女性，并预测至2035年的趋势。 方法：本研究利用全球疾病负担研究的数据，分析了1990年至2021年全球及区域甲状腺癌负担，重点关注育龄女性。评估的关键指标包括不同区域甲状腺癌的发病率、死亡率和伤残调整生命年（DALYs）。采用统计分析技术比较各区域和国家的负担情况，研究年龄、性别和社会人口指数（SDI）对疾病负担的影响。使用贝叶斯年龄-时期-队列模型预测2022年至2035年甲状腺癌的发病率、死亡率和DALYs。 结果：2021年全球范围内，育龄女性中有67558例甲状腺癌新发病例，3260例死亡，206508个伤残调整生命年。与1990年相比，新发病例增加了156.86%，死亡人数增加了52.33%，伤残调整生命年增加了61.72%。每10万人口的年龄标准化发病率（ASIR）、死亡率（ASMR）和伤残调整生命年率（ASDR）分别为3.37、0.16和10.38。年龄标准化发病率的估计年变化百分比（EAPC）为1.47，呈上升趋势，而年龄标准化死亡率和伤残调整生命年率的EAPC分别为-0.35和-0.05，呈下降趋势。育龄女性甲状腺癌患者的负担呈现出显著的年龄相关趋势，在45-49岁年龄组达到峰值。甲状腺癌负担存在显著的区域和国家差异，这与社会人口指数密切相关。预计到2035年，全球育龄女性中与甲状腺癌相关的发病率、死亡率和伤残调整生命年将显著增加。 结论：在过去30年中，全球女性甲状腺癌发病率显著上升，死亡率和伤残调整生命年率略有下降。显著的区域和国家差异与社会人口指数密切相关。随着人口老龄化和发病率持续上升，针对性的预防和治疗策略，特别是在社会人口指数较低的地区，对于有效降低死亡率和伤残调整生命年至关重要。
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