Shah Het, Prabhakaran A, Praveen Iyyappan, Farook Umar
Department of Orthopaedics, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Pondicherry, India.
J Pharm Bioallied Sci. 2025 Jun;17(Suppl 2):S1689-S1691. doi: 10.4103/jpbs.jpbs_263_25. Epub 2025 Jun 18.
Plantar fasciitis, a chronic inflammatory condition characterized by heel pain, significantly impacts daily functioning. While corticosteroid injections are a common treatment, they are associated with limitations such as short-term efficacy and potential complications.
This prospective interventional study was conducted at Mahatma Gandhi Medical College and Research Institute, Puducherry, between August 2022 and May 2024. A total of 60 patients diagnosed with plantar fasciitis, aged 18-70 years, were randomly divided into two groups: the platelet-rich plasma (PRP) group (30 patients) and the corticosteroid group (30 patients). PRP therapy was administered using the peppering technique, while the corticosteroid group received 80 mg methylprednisolone injections. Pain and functional outcomes were assessed at baseline, second, fourth, eighth, and 12 weeks using the visual analog scale (VAS) and Foot and Ankle Ability Measure (FAAM).
The mean age of participants was 47.30 ± 10.75 years in the PRP group and 46.13 ± 10.58 years in the corticosteroid group. Females constituted 53.3% of the PRP group and 60% of the corticosteroid group. Significant reductions in VAS scores were observed in the PRP group compared to the corticosteroid group at the second week (5.53 ± 0.776 vs. 6.47 ± 0.937, < 0.001), fourth week (4.70 ± 0.466 vs. 5.27 ± 0.868, = 0.003), and 12 week (2.10 ± 0.712 vs. 2.77 ± 0.858, = 0.002). Functional improvement, measured by FAAM scores, was significantly greater in the PRP group at the 12 week (91.03 ± 3.943 vs. 86.13 ± 6.388, = 0.001).
PRP therapy is a superior alternative to corticosteroid injections for the management of plantar fasciitis, providing sustained pain relief and improved functional outcomes over a 12-week period. Further large-scale, long-term studies are recommended to validate these findings.
足底筋膜炎是一种以足跟疼痛为特征的慢性炎症性疾病,严重影响日常功能。虽然皮质类固醇注射是一种常见的治疗方法,但它们存在诸如短期疗效和潜在并发症等局限性。
这项前瞻性干预研究于2022年8月至2024年5月在本地治里的圣雄甘地医学院和研究所进行。共有60例年龄在18 - 70岁之间被诊断为足底筋膜炎的患者被随机分为两组:富血小板血浆(PRP)组(30例患者)和皮质类固醇组(30例患者)。PRP治疗采用点状注射技术,而皮质类固醇组接受80mg甲泼尼龙注射。在基线、第2周、第4周、第8周和第12周使用视觉模拟量表(VAS)和足踝功能测量量表(FAAM)评估疼痛和功能结果。
PRP组参与者的平均年龄为47.30±10.75岁,皮质类固醇组为46.13±10.58岁。PRP组女性占53.3%,皮质类固醇组女性占60%。与皮质类固醇组相比,PRP组在第2周(5.53±0.776对6.47±0.937,<0.001)、第4周(4.70±0.466对5.27±0.868,=0.003)和第12周(2.10±0.712对2.77±0.858,=0.002)时VAS评分显著降低。以FAAM评分衡量的功能改善在第12周时PRP组显著更大(91.03±3.943对86.13±6.388,=0.001)。
对于足底筋膜炎的治疗,PRP治疗是皮质类固醇注射的一种更好的替代方法,在12周内提供持续的疼痛缓解和改善的功能结果。建议进一步进行大规模、长期研究以验证这些发现。