脱矿冻干骨同种异体移植和羊膜在牙周骨缺损中的作用评估：一项临床和影像学研究
Evaluation of the Role of Demineralized Freeze-Dried Bone Allograft and Amniotic Membrane in Periodontal Osseous Defects: A Clinical and Radiographic Study.
作者信息
Chandra Deepti, Khan Md Arif, Gowrav Piyush, Jaiswal Rajeev Kumar, Gupta Sanjay, Bhat Anu
机构信息
Department of Periodontology, Career Postgraduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India.
Department of Periodontology, Babu Banarasi Das College of Dental Sciences, Lucknow, Uttar Pradesh, India.
出版信息
J Pharm Bioallied Sci. 2025 Jun;17(Suppl 2):S1814-S1816. doi: 10.4103/jpbs.jpbs_455_25. Epub 2025 Jun 18.
BACKGROUND
Periodontitis is an inflammatory disease of the supporting tissue leading to progressive destruction of periodontal ligament and alveolar bone, often resulting in furcation defects. Treatment typically involves periodontal flap surgery with osteoplasty and odontoplasty using materials like hydroxyapatite and demineralized freeze-dried bone allograft (DFDBA). This study compares the efficacy of DFDBA alone and combined with amniotic membrane (AM) in the treatment of grade II furcation defects.
MATERIALS AND METHODS
30 patients with grade II furcation defects in mandibular first molars were randomly divided into two groups: Group A (control) received DFDBA, and Group B (experimental) received DFDBA with AM. Clinical and radiographic parameters, including plaque index (PI), gingival index (GI), vertical probing depths (VPD), clinical attachment level (CAL) and radiographic bone gain, were assessed at baseline, 1, 3, and 6 months.
CONCLUSION
DFDBA, with or without AM, significantly regenerates grade II furcation defects.
背景
牙周炎是一种支持组织的炎症性疾病，会导致牙周韧带和牙槽骨的渐进性破坏，常导致根分叉病变。治疗通常包括牙周翻瓣手术以及使用羟基磷灰石和脱矿冻干骨同种异体移植（DFDBA）等材料进行骨成形术和牙成形术。本研究比较了单独使用DFDBA和联合羊膜（AM）治疗II度根分叉病变的疗效。
材料与方法
30名下颌第一磨牙患有II度根分叉病变的患者被随机分为两组：A组（对照组）接受DFDBA，B组（实验组）接受DFDBA联合AM。在基线、1个月、3个月和6个月时评估临床和影像学参数，包括菌斑指数（PI）、牙龈指数（GI）、垂直探诊深度（VPD）、临床附着水平（CAL）和影像学骨增量。
结论
无论是否联合AM，DFDBA均可显著使II度根分叉病变再生。
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