Zhang Lin, Zhao Yaqi, Shi Xiaolu, Wu Fan, Shen Yi
Special Education College, Beijing Union University, Beijing, China.
Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China.
Front Cell Dev Biol. 2025 Jun 27;13:1590009. doi: 10.3389/fcell.2025.1590009. eCollection 2025.
As a developmental vision disorder, amblyopia has traditionally been studied with a focus on neurons. However, the neurovascular unit (NVU), a dynamic functional complex of neurons, blood vessels, and glial cells, has recently been implicated in amblyopia. This review systematically discusses the pathological changes and functional interactions of the NVU in retina and brain in amblyopia patients and experimental models, providing a new perspective for clinical intervention.
作为一种发育性视觉障碍，传统上对弱视的研究主要集中在神经元上。然而，神经血管单元（NVU）是由神经元、血管和神经胶质细胞组成的动态功能复合体，最近被认为与弱视有关。本文综述系统地讨论了弱视患者和实验模型中视网膜和大脑NVU的病理变化及功能相互作用，为临床干预提供了新的视角。
