Mukherjee Sukriti, Kalita Jayashree, Chatterjee Trishita, Zidane Zinedine, Sarkar Sukanto
Department of Psychiatry, All India Institute of Medical Sciences, Kalyani, West Bengal, India.
Indian J Psychiatry. 2025 Jun;67(6):627-630. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_200_25. Epub 2025 May 16.
Auditory hallucinations affect 60%-80% of schizophrenia patients, often causing distress and functional impairment. Despite antipsychotic treatment, 30% remain resistant. Dysfunctional prefrontal-temporal connectivity has been found to be associated with these symptoms. Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulation technique that targets the dysfunctional area and is being used for treatment of persistent auditory hallucinations in Schizophrenia with mixed results. Continuous Theta Burst Stimulation (cTBS) is a novel neuromodulation technique that works on the principals of rTMS with similar or more robust clinical efficacy.
We describe the cases of three patients where cTBS was applied.
Significant improvement in auditory hallucinations was noticed in all three patients. While this evidence must be interpreted with caution, future studies on this topic with robust protocol to be conducted.
幻听影响60%-80%的精神分裂症患者，常导致痛苦和功能障碍。尽管进行了抗精神病治疗，但仍有30%的患者对此耐药。已发现前额叶-颞叶连接功能障碍与这些症状有关。重复经颅磁刺激（rTMS）是一种针对功能障碍区域的神经调节技术，目前正用于治疗精神分裂症患者的持续性幻听，但其效果不一。连续theta爆发刺激（cTBS）是一种新型神经调节技术，其作用原理与rTMS相似，临床疗效相当或更强。
我们描述了应用cTBS治疗的3例患者的病例。
所有3例患者的幻听症状均有显著改善。虽然对这一证据的解读必须谨慎，但未来需要采用严格方案对该主题进行研究。
