Manojlović Marina, Milosavljević Filip, Atanasov Andrea, Batinić Bojan, Sitarica Pavle, Pešić Vesna, Jukić Marin M
Department of Physiology, Faculty of Pharmacy, University of Belgrade, Serbia.
Department of Psychiatry and Psychotherapy, School of Medicine, Technische Universität München, Germany.
Neurosci Appl. 2024 Apr 14;3:104068. doi: 10.1016/j.nsa.2024.104068. eCollection 2024.
As one of the main characteristics of adolescence is the increased desire for social interaction and formation of meaningful relationships, it represents a particularly vulnerable period for social stressors. Moreover, social isolation during adolescence can significantly alter brain function and increase the likelihood of anxiety disorders in early adulthood. The aim of this retrospective meta-analysis and prospective behavioural experiment was to investigate whether chronic isolation stress during adolescence causes generalised and social anxiety-like behaviour in rodents. The meta-analysis of previously published data showed that social isolation during adolescence leads to an increase in generalised anxiety-like behaviour exclusively in male isolated rodents and has ambiguous effect on social anxiety-like behaviour. In the subsequent prospective experiment, Sprague-Dawley rats of both sexes were subjected to six weeks of social isolation and their behaviour was investigated in the open field, elevated plus maze, and three-chamber test. Consistent with the retrospective literature analysis, social isolation in adolescence increased generalised anxiety-like behaviour exclusively in males, as indicated by a decrease in time spent in the centre of the open field and open arms of the elevated plus maze, compared to controls. Both male and female isolated rats showed an increase in sociability in the three-chamber test, as indicated by the increase in the preference ratio for social versus neutral stimuli, compared to controls. Altogether, social isolation leads to an increase in generalised anxiety-like behaviour exclusively in males and to increased sociability in both males and females.
由于青少年期的主要特征之一是对社交互动的渴望增加以及形成有意义的人际关系，所以这一时期对社会压力源而言特别脆弱。此外，青少年期的社会隔离会显著改变大脑功能，并增加成年早期患焦虑症的可能性。这项回顾性荟萃分析和前瞻性行为实验的目的是研究青少年期的慢性隔离应激是否会导致啮齿动物出现广泛性焦虑和社交焦虑样行为。对先前发表数据的荟萃分析表明，青少年期的社会隔离仅会导致雄性隔离啮齿动物的广泛性焦虑样行为增加，而对社交焦虑样行为的影响不明确。在随后的前瞻性实验中，对两性的斯普拉格-道利大鼠进行了六周的社会隔离，并在旷场试验、高架十字迷宫试验和三室试验中对它们的行为进行了研究。与回顾性文献分析一致，青少年期的社会隔离仅增加了雄性的广泛性焦虑样行为，与对照组相比，这表现为在旷场中央和高架十字迷宫开放臂停留时间的减少。与对照组相比，雄性和雌性隔离大鼠在三室试验中的社交性均有所增加，这表现为对社交刺激与中性刺激的偏好比率增加。总之，社会隔离仅导致雄性的广泛性焦虑样行为增加，而导致雄性和雌性的社交性均增加。
