Yasir Muhammad, Abdelgabar Abdelnassir, Elsayed Mohammed, Hasan Md Nayeem, Osman Sherif
Acute Medicine, Diana, Princess of Wales Hospital, Grimsby, GBR.
Cureus. 2025 Jun 13;17(6):e85930. doi: 10.7759/cureus.85930. eCollection 2025 Jun.
Dermatomyositis (DM) is a rare acquired autoimmune myopathy characterized by proximal muscle weakness, inflammation, and a typical skin rash. It is considered one of the idiopathic inflammatory myopathies (IIM), a group of heterogeneous systemic diseases that include DM, polymyositis, and inclusion body myositis. A significant portion of patients with IIM, particularly adults, can have an association with malignancy, usually preceded by muscle and skin symptoms. We report a case of a 67-year-old man who presented to the accident and emergency department with a six-week history of proximal myopathy in the upper and lower limbs and a skin rash. After a series of investigations, the patient was diagnosed with anti-TIF1γ-positive DM and concurrent lung cancer. DM is a paraneoplastic disorder that should always prompt a search for malignancy. Early detection of anti-TIF1γ autoantibodies can facilitate an early diagnosis of CAD, allowing for prompt therapeutic interventions. Several autoantibodies with different clinical and prognostic significance have been detected in IIM. However, the recently discovered anti-TIF1γ antibodies appear to be strongly associated with malignancy.
皮肌炎（DM）是一种罕见的获得性自身免疫性肌病，其特征为近端肌无力、炎症和典型的皮疹。它被认为是特发性炎性肌病（IIM）之一，这是一组异质性全身性疾病，包括皮肌炎、多发性肌炎和包涵体肌炎。相当一部分IIM患者，尤其是成年人，可能与恶性肿瘤有关，通常在出现肌肉和皮肤症状之前。我们报告一例67岁男性患者，他因上下肢近端肌病伴皮疹6周就诊于急诊科。经过一系列检查，该患者被诊断为抗TIF1γ阳性皮肌炎并并发肺癌。皮肌炎是一种副肿瘤性疾病，应始终促使医生寻找恶性肿瘤。早期检测抗TIF1γ自身抗体有助于早期诊断皮肌炎，从而能够及时进行治疗干预。在IIM中已检测到几种具有不同临床和预后意义的自身抗体。然而，最近发现的抗TIF1γ抗体似乎与恶性肿瘤密切相关。
