Sulakvelidze Ketevan, Dolidze Nino
Department of Cardiology, Caucasus Medical Centre, Tbilisi, GEO.
Cureus. 2025 Jun 12;17(6):e85839. doi: 10.7759/cureus.85839. eCollection 2025 Jun.
Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm characterized by elevated platelet counts and an increased risk of thrombotic or hemorrhagic complications. It typically affects older individuals, with a higher prevalence in women, and is frequently associated with Janus kinase 2 (JAK2) mutations. While many cases follow an indolent course, major thrombotic events such as pulmonary embolism may occur. We report the case of a 72-year-old female patient with a known history of ET who presented with an acute onset of dyspnea and pleuritic chest pain. Computed tomography pulmonary angiography confirmed pulmonary artery thromboembolism. Laboratory tests revealed significant thrombocytosis. The patient was treated with anticoagulation and cytoreductive therapy, resulting in clinical improvement. This case highlights the importance of early recognition of thrombotic complications in patients with ET, even when they are receiving ongoing treatment.
原发性血小板增多症（ET）是一种慢性骨髓增殖性肿瘤，其特征为血小板计数升高以及血栓形成或出血并发症风险增加。它通常影响老年个体，女性患病率更高，且常与Janus激酶2（JAK2）突变相关。虽然许多病例病程进展缓慢，但可能会发生诸如肺栓塞等严重血栓事件。我们报告一例72岁女性患者，她有ET病史，出现急性呼吸困难和胸膜炎性胸痛。计算机断层扫描肺动脉造影证实为肺动脉血栓栓塞。实验室检查显示明显的血小板增多。该患者接受了抗凝和减细胞治疗，临床症状得到改善。该病例强调了即使在接受持续治疗的ET患者中，早期识别血栓并发症的重要性。
