Yuan Xue-Ting, Wang Jing-Ru, Yang Ying, Ren Jian-Gang
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Xianning Medical College, Hubei University of Science and Technology, Xianning, China.
J Cancer. 2025 Jun 12;16(9):2787-2799. doi: 10.7150/jca.110721. eCollection 2025.
S-palmitoylation (hereinafter referred to as palmitoylation) is a reversible lipid modification that has recently received considerable attention in cancer research. Despite its known association with tumour progression and treatment response, it remains unclear how palmitoylation could be targeted for enhancing therapeutic outcomes in oral squamous cell carcinoma (OSCC). This review summarises palmitoylated proteins common in various cancers and highlights emerging targets specific to OSCC, emphasising their roles in protein stability, signalling pathways, and cellular behaviour. Additionally, we explore new trends in targeting palmitoylated proteins to manage cancer progression and bolster the immune response in OSCC. Furthermore, this review highlights existing knowledge gaps and calls for detailed investigations into OSCC-specific palmitoylation mechanisms, including the expression levels of palmitoylated proteins and palmitoylation enzymes and their effect on OSCC signalling pathways.
S-棕榈酰化（以下简称棕榈酰化）是一种可逆的脂质修饰，近年来在癌症研究中受到了广泛关注。尽管已知其与肿瘤进展和治疗反应有关，但尚不清楚如何靶向棕榈酰化以提高口腔鳞状细胞癌（OSCC）的治疗效果。本综述总结了各种癌症中常见的棕榈酰化蛋白，并强调了OSCC特有的新兴靶点，重点介绍了它们在蛋白质稳定性、信号通路和细胞行为中的作用。此外，我们探讨了靶向棕榈酰化蛋白以控制癌症进展和增强OSCC免疫反应的新趋势。此外，本综述突出了现有的知识空白，并呼吁对OSCC特异性棕榈酰化机制进行详细研究，包括棕榈酰化蛋白和棕榈酰化酶的表达水平及其对OSCC信号通路的影响。
