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[急性淋巴细胞白血病诊断时儿童的高血糖水平]

[High glucose levels in children at diagnosis of acute lymphoblastic leukemia].

作者信息

Paque-Bautista Carlos, Aranda-Romo Sara Aurora, Medel-Sánchez Andrea, González Alma Patricia, Cerritos-García Dania Eunice, Reyes-Sosa Arturo Maximiliano, Sosa-Bustamante Gloria Patricia

机构信息

Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, Unidad Médica de Alta Especialidad, Hospital de Gineco Pediatría No. 48, Dirección de Educación e Investigación en Salud. León, Guanajuato, México.

Universidad de Guanajuato, Campus León, División de Ciencias de la Salud, Departamento de Medicina y Nutrición. León, Guanajuato, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2025 Jul 1;63(4):e6664. doi: 10.5281/zenodo.15850431.

DOI:10.5281/zenodo.15850431
PMID:40658435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12283111/
Abstract

BACKGROUND

Acute lymphoblastic leukemia (ALL) is the most common neoplasm in children. Although survival rates have improved, considerable mortality persists, partly due to metabolic complications. ALL is characterized by metabolic reprogramming, which may clinically manifest as elevated serum glucose (SG) levels at disease onset.

OBJECTIVE

To analyze whether there are differences in SG levels between newly diagnosed pediatric patients with ALL and a control group.

MATERIALS AND METHODS

A case-control study was conducted. Pediatric patients aged between 1 month and 15 years 11 months, of both sexes, were included and divided into two groups. ALL Group: Patients with a recent diagnosis of ALL, prior to the initiation of induction therapy. Control Group: Patients without a diagnosis of ALL. Sociodemographic, anthropometric, and biochemical data were obtained from clinical records.

RESULTS

A total of 142 patients were analyzed, 71 in the ALL Group and 71 in the Control Group. The median age was 6 years (IQR 3-11), and 54.92% were male. The ALL Group showed significantly higher SG levels compared to the Control Group. In addition, a higher risk of elevated SG was observed in the ALL Group.

CONCLUSIONS

This study demonstrates elevated SG levels in children with newly diagnosed ALL, which may be related to the metabolic reprogramming of leukemic cells.

摘要

背景

急性淋巴细胞白血病（ALL）是儿童最常见的肿瘤。尽管生存率有所提高，但仍有相当数量的患者死亡，部分原因是代谢并发症。ALL的特征是代谢重编程，在疾病发作时临床上可能表现为血清葡萄糖（SG）水平升高。

目的

分析新诊断的ALL儿科患者与对照组之间SG水平是否存在差异。

材料与方法

进行了一项病例对照研究。纳入年龄在1个月至15岁11个月之间的儿科患者，分为两组。ALL组：近期诊断为ALL且尚未开始诱导治疗的患者。对照组：未诊断为ALL的患者。从临床记录中获取社会人口统计学、人体测量学和生化数据。

结果

共分析了142例患者，ALL组71例，对照组71例。中位年龄为6岁（四分位间距3 - 11岁），54.92%为男性。ALL组的SG水平显著高于对照组。此外，ALL组中SG升高的风险更高。

结论

本研究表明新诊断的ALL儿童SG水平升高，这可能与白血病细胞的代谢重编程有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/87819517fd2a/04435117-63-4-e6664-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/e2171339c32f/04435117-63-4-e6664-for001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/3c3871456963/04435117-63-4-e6664-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/45f11625d6a9/04435117-63-4-e6664-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/82a9865b71a0/04435117-63-4-e6664-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/87819517fd2a/04435117-63-4-e6664-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/e2171339c32f/04435117-63-4-e6664-for001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/3c3871456963/04435117-63-4-e6664-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/45f11625d6a9/04435117-63-4-e6664-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/82a9865b71a0/04435117-63-4-e6664-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e1/12283111/87819517fd2a/04435117-63-4-e6664-f004.jpg

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Cumulative exposure to impaired fasting glucose and gastrointestinal cancer risk: A nationwide cohort study.空腹血糖受损的累积暴露与胃肠道癌症风险：一项全国性队列研究。
Cancer. 2024 May 15;130(10):1807-1815. doi: 10.1002/cncr.35197. Epub 2024 Jan 10.
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14. Children and Adolescents: Standards of Care in Diabetes-2024.14. 儿童和青少年：2024 年糖尿病护理标准。
Diabetes Care. 2024 Jan 1;47(Suppl 1):S258-S281. doi: 10.2337/dc24-S014.
4
Proactive Glucose Screening Tool Effective for Time-sensitive Identification of Hyperglycemia in Childhood Cancer Patients.主动血糖筛查工具可有效及时识别儿童癌症患者的高血糖症。
J Pediatr Hematol Oncol. 2023 Aug 1;45(6):e695-e701. doi: 10.1097/MPH.0000000000002674. Epub 2023 Apr 10.
5
2-Deoxy-D-glucose simultaneously targets glycolysis and Wnt/β-catenin signaling to inhibit cervical cancer progression.2-脱氧-D-葡萄糖同时靶向糖酵解和 Wnt/β-连环蛋白信号通路抑制宫颈癌进展。
IUBMB Life. 2023 Jul;75(7):609-623. doi: 10.1002/iub.2706. Epub 2023 Feb 21.
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