Familial paracentric inversion inv(2)(q31q36).

A paracentric inversion of chromosome 2 is described for the first time. The breakpoints were localized in the bands q31 and q36. The paracentric inversion was initially identified in a female with repeated abortions and thereafter detected in eight other family members over three generations. The meiotic consequences and the risk for liveborn unbalanced chromosomal recombinants is discussed.