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Impact of TP53 variants and germline mutations on allogeneic stem cell transplantation outcomes in acute myeloid leukemia and myelodysplastic neoplasms.

作者信息

Zhao Yeqian, Cao Weijie, Shi Jimin, Cao Yang, Lu Ying, Luo Yi, Ouyang Guifang, Chen Lieguang, Lan Jianping, Song Xiaolu, Chen Yi, Yu Li, Yu Jian, Lai Xiaoyu, Liu Lizhen, Fu Huarui, Ye Yishan, Yang Luxin, Mo Xiaodong, Hu Xiaoxia, Huang He, Zhao Yanmin

机构信息

Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.

Institute of Hematology, Zhejiang University, Hangzhou, China.

出版信息

Leukemia. 2025 Jul 14. doi: 10.1038/s41375-025-02672-w.

DOI:10.1038/s41375-025-02672-w
PMID:40659988
Abstract
摘要

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Impact of TP53 variants and germline mutations on allogeneic stem cell transplantation outcomes in acute myeloid leukemia and myelodysplastic neoplasms.TP53变异和种系突变对急性髓系白血病和骨髓增生异常综合征异基因干细胞移植结局的影响。
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4
Early identification of TP53 mutations and TP53 allelic state in myelodysplastic neoplasms and acute myeloid leukemia via point-of-care p53 immunohistochemistry.通过即时护理p53免疫组织化学早期识别骨髓增生异常肿瘤和急性髓系白血病中的TP53突变及TP53等位基因状态。
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本文引用的文献

1
Prognostic impact of 'multi-hit' <i>versus</i> 'single-hit' <i>TP53</i> alteration in patients with acute myeloid leukemia: results from the Consortium on Myeloid Malignancies and Neoplastic Diseases.急性髓系白血病患者中“多打击”与“单打击”<i>TP53</i>改变的预后影响：来自髓系恶性肿瘤和肿瘤疾病联盟的研究结果。
Haematologica. 2024 Nov 1;109(11):3533-3542. doi: 10.3324/haematol.2024.285000.
2
TP53 in MDS and AML: Biological and clinical advances.TP53 在 MDS 和 AML 中的作用：生物学和临床进展。
Cancer Lett. 2024 Apr 28;588:216767. doi: 10.1016/j.canlet.2024.216767. Epub 2024 Feb 27.
3
Insights from TARGET-seq: Inflammation drives -mediated clonal evolution.
来自TARGET-seq的见解：炎症驱动 - 介导的克隆进化。 （注：原文中“-mediated”前似乎缺失了某个词）
Innovation (Camb). 2024 Jan 5;5(2):100572. doi: 10.1016/j.xinn.2024.100572. eCollection 2024 Mar 4.
4
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.单细胞多组学鉴定慢性炎症是 TP53 突变型白血病演变的驱动因素。
Nat Genet. 2023 Sep;55(9):1531-1541. doi: 10.1038/s41588-023-01480-1. Epub 2023 Sep 4.
5
Interplay of TP53 allelic state, blast count, and complex karyotype on survival of patients with AML and MDS.TP53 等位基因状态、 blast 计数和复杂核型对 AML 和 MDS 患者生存的相互影响。
Blood Adv. 2023 Sep 26;7(18):5540-5548. doi: 10.1182/bloodadvances.2023010312.
6
Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.胚系 RUNX1、GATA2 和 DDX41 变异导致的遗传性血液系统恶性肿瘤的体细胞突变图谱。
Blood Adv. 2023 Oct 24;7(20):6092-6107. doi: 10.1182/bloodadvances.2023010045.
7
Haploidentical haematopoietic stem cell transplantation for TP53-mutated acute myeloid leukaemia.单倍型相合造血干细胞移植治疗TP53突变的急性髓系白血病
Br J Haematol. 2023 Feb;200(4):494-505. doi: 10.1111/bjh.18538. Epub 2022 Nov 8.
8
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data.国际髓系肿瘤和急性白血病分类：整合形态学、临床和基因组数据。
Blood. 2022 Sep 15;140(11):1200-1228. doi: 10.1182/blood.2022015850.
9
Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome.突变型 TP53 急性髓系白血病和高危骨髓增生异常综合征的分子特征。
Blood. 2022 Apr 14;139(15):2347-2354. doi: 10.1182/blood.2021014472.
10
Acute Myeloid Leukemia and Myelodysplastic Syndromes with Aberrations - A Distinct Stem Cell Disorder.急性髓系白血病和伴异常的骨髓增生异常综合征——一种独特的干细胞疾病。
Clin Cancer Res. 2020 Oct 15;26(20):5304-5309. doi: 10.1158/1078-0432.CCR-20-2272. Epub 2020 Aug 14.