Zhu Guang, Kan Chunting, Cao Changchun, Zhu Hong
Department of Endocrinology, The Affiliated Suqian Hospital of Xuzhou Medical University, Nanjing Drum Tower Hospital Group Suqian Hospital, Suqian, 223800, People's Republic of China.
BMC Endocr Disord. 2025 Jul 14;25(1):175. doi: 10.1186/s12902-025-01998-x.
This study explored the application value of high mobility group box 1 (HMGB1) and toll-like receptor 4 (TLR4) levels in the diagnosis of type 2 diabetes mellitus (T2DM) with osteoporosis (OP).
This was a cross-sectional study of 126 patients. The patients with T2DM was stratified into the following three subgroups: normal bone mass, osteopenia, and OP. Comparative analyses of general data and biochemical indices were performed, and Pearson's correlation was used to assess the relationship among HMGB1, TLR4 levels, and bone mineral density (BMD). Multivariate logistic regression identified risk factors in patients with T2DM. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of HMGB1 and TLR4 levels for OP in patients with T2DM.
HMGB1 and TLR4 levels were significantly higher in the OP group than in the normal bone mass and osteopenia groups (p < 0.05). Pearson's correlation analysis revealed a negative association among BMD, HMGB1, and TLR4 levels. Multivariate logistic regression analysis identified Mg, HMGB1, and TLR4 as significant OP risk factors for T2DM. ROC curve analysis demonstrated that the areas under the curve for HMGB1 and TLR4 in predicting OP in patients with T2DM were 0.828 and 0.854, respectively, with respective sensitivities of 79.4% and 94.1% and respective specificities of 78.3% and 58.7%.
Serum HMGB1 and TLR4 levels may be potential biomarkers for OP in patients with T2DM.
Not applicable.
本研究探讨了高迁移率族蛋白B1（HMGB1）和Toll样受体4（TLR4）水平在2型糖尿病（T2DM）合并骨质疏松症（OP）诊断中的应用价值。
这是一项对126例患者的横断面研究。将T2DM患者分为以下三个亚组：骨量正常、骨量减少和OP。对一般资料和生化指标进行比较分析，并采用Pearson相关性分析评估HMGB1、TLR4水平与骨密度（BMD）之间的关系。多因素logistic回归分析确定T2DM患者的危险因素。采用受试者工作特征（ROC）曲线评估HMGB1和TLR4水平对T2DM患者OP的诊断效能。
OP组的HMGB1和TLR4水平显著高于骨量正常组和骨量减少组（p < 0.05）。Pearson相关性分析显示BMD、HMGB1和TLR4水平之间呈负相关。多因素logistic回归分析确定镁、HMGB1和TLR4是T2DM患者发生OP的重要危险因素。ROC曲线分析表明，HMGB1和TLR4预测T2DM患者OP的曲线下面积分别为0.828和0.854，敏感性分别为79.4%和94.1%，特异性分别为78.3%和58.7%。
血清HMGB1和TLR4水平可能是T2DM患者OP的潜在生物标志物。
不适用。
