Department of Epidemiology and Biostatistics, School of Public Health, University of Nevada, Las Vegas, Las Vegas, NV, 89154, USA.
Nevada Institute of Personalized Medicine, College of Science, University of Nevada, Las Vegas, Las Vegas, NV, 89154, USA.
Sci Rep. 2021 Feb 12;11(1):3693. doi: 10.1038/s41598-021-83263-4.
This study aimed to examine how bone health changed among T2DM patients in the past decade. Continuous National Health and Nutrition Examination Survey (NHANES) data from 2005-2006 to 2013-2014 were analyzed to examine the trends of bone mineral density (BMD) and the prevalence trends of osteoporosis osteopenia among T2DM patients and non-diabetic people aged 40 years and older. The age- and BMI-adjusted mean BMD of the femur neck for the four NHANES cycles decreased linearly in both T2DM patients and non-diabetic people (both P ≤ 0.009). Among women with T2DM, the mean BMD in 2013-2014 was significantly lower than that in 2005-2006, even after adjusting for multiple covariates. During 2005-2014, the prevalence of osteoporosis among T2DM patients and non-diabetic people increased but with no significant linear trend (both P > 0.05), while the prevalence of osteopenia in the two populations increased linearly (both P < 0.04). Age- and BMI-adjusted mean BMD decreased in 2013-2014 in patients with T2DM and non-diabetic people, while the prevalence of osteoporosis and osteopenia increased in both groups.
本研究旨在探讨在过去十年中，2 型糖尿病患者的骨骼健康状况发生了怎样的变化。分析了 2005-2006 年至 2013-2014 年连续的国家健康和营养检查调查（NHANES）数据，以研究 2 型糖尿病患者和年龄在 40 岁及以上的非糖尿病患者的骨密度（BMD）趋势和骨质疏松症/骨量减少的流行趋势。在四个 NHANES 周期中，经过年龄和 BMI 调整后的股骨颈平均 BMD 在 2 型糖尿病患者和非糖尿病患者中呈线性下降（均 P≤0.009）。在患有 2 型糖尿病的女性中，即使经过多变量调整后，2013-2014 年的平均 BMD 仍明显低于 2005-2006 年。2005-2014 年间，2 型糖尿病患者和非糖尿病患者的骨质疏松症患病率增加，但无显著线性趋势（均 P＞0.05），而这两个群体的骨量减少患病率呈线性增加（均 P＜0.04）。2013-2014 年，2 型糖尿病患者和非糖尿病患者的年龄和 BMI 调整后的平均 BMD 均下降，而两组的骨质疏松症和骨量减少的患病率均增加。
