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揭开隐匿的元凶:缺铁性贫血背景下的胃神经内分泌肿瘤

Unmasking the Silent Culprit: Gastric Neuroendocrine Tumor in the Setting of Iron Deficiency Anemia.

作者信息

Serjilus Ashley, Zimmer Sarah K, Bush Allison M, De Luca-Johnson Javier N, Keenan Bryan J, Harvey Amie L

机构信息

Internal Medicine, Naval Medical Center Portsmouth, Portsmouth, USA.

Gastroenterology, Naval Medical Center Portsmouth, Portsmouth, USA.

出版信息

Cureus. 2025 Jun 14;17(6):e86010. doi: 10.7759/cureus.86010. eCollection 2025 Jun.

DOI:10.7759/cureus.86010
PMID:40662018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12258610/
Abstract

Gastric neuroendocrine tumors (GNETs) are uncommon neoplasms; it is classified into four subtypes based on low to high risk of progression and developing metastasis. GNETs can be asymptomatic or present with nonspecific signs and symptoms, including dyspepsia and iron deficiency anemia (IDA). In people who menstruate, iron deficiency is often attributed to menstrual cycles, and they may not undergo investigation for gastrointestinal sources. We present a case of a young female with long-standing iron deficiency and menorrhagia, who was found to have a rare GNET, most consistent with a type 3 subset.

摘要

胃神经内分泌肿瘤(GNETs)是一种罕见的肿瘤;根据进展和发生转移的低到高风险,它可分为四种亚型。GNETs 可能无症状,或表现为非特异性体征和症状,包括消化不良和缺铁性贫血(IDA)。在有月经的人群中,缺铁通常归因于月经周期,他们可能不会接受胃肠道来源的检查。我们报告一例长期缺铁和月经过多的年轻女性病例,该患者被发现患有罕见的 GNET,最符合 3 型亚型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8cc/12258610/314dfdb8f4f9/cureus-0017-00000086010-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8cc/12258610/e9343b215e4e/cureus-0017-00000086010-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8cc/12258610/a778151332fa/cureus-0017-00000086010-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8cc/12258610/d273a8f60637/cureus-0017-00000086010-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8cc/12258610/314dfdb8f4f9/cureus-0017-00000086010-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8cc/12258610/e9343b215e4e/cureus-0017-00000086010-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8cc/12258610/a778151332fa/cureus-0017-00000086010-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8cc/12258610/d273a8f60637/cureus-0017-00000086010-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8cc/12258610/314dfdb8f4f9/cureus-0017-00000086010-i04.jpg

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本文引用的文献

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ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors.《欧洲神经内分泌肿瘤学会功能性胰腺神经内分泌肿瘤和非功能性胰腺神经内分泌肿瘤患者管理共识指南更新》
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胃肠胰神经内分泌肿瘤
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Chromogranin A: is it a useful marker of neuroendocrine tumors?嗜铬粒蛋白A:它是神经内分泌肿瘤的有用标志物吗?
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TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system.前肠(神经)内分泌肿瘤的TNM分期:一项包括分级系统的共识提议。
Virchows Arch. 2006 Oct;449(4):395-401. doi: 10.1007/s00428-006-0250-1. Epub 2006 Sep 12.
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