伴刀豆球蛋白A对狂犬病病毒感染CER细胞早期事件的影响。
Effect of concanavalin A on the early events of rabies virus infection of CER cells.
作者信息
Conti C, Tsiang H
出版信息
Intervirology. 1985;24(3):166-9. doi: 10.1159/000149636.
The effect of concanavalin A on rabies virus infection of CER cells was investigated. Pretreatment of CER cells with concanavalin A inhibited cellular susceptibility to rabies virus infection. The lectin also was found to be inhibitory when applied after the viral binding step. Moreover, the lectin had a direct inhibitory effect on the infectivity of the virion. These lectin-mediated inhibitions could be reversed by alpha-D-methyl-mannopyranoside. These complex effects are discussed with regard to the mechanism of rabies virus entry into CER cells.
研究了伴刀豆球蛋白A对CER细胞狂犬病病毒感染的影响。用伴刀豆球蛋白A预处理CER细胞可抑制细胞对狂犬病病毒感染的易感性。还发现该凝集素在病毒结合步骤后应用时也具有抑制作用。此外，该凝集素对病毒粒子的感染性有直接抑制作用。这些凝集素介导的抑制作用可被α-D-甲基甘露糖苷逆转。针对狂犬病病毒进入CER细胞的机制对这些复杂效应进行了讨论。
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