Wheeler Brenden P, Medd Kyle, Woodworth Kaitlyn E, Davenport Huyer Locke
School of Biomedical Engineering, Faculties of Medicine and Engineering, Dalhousie University, Halifax NS B3H 4R2, Canada.
Department of Microbiology & Immunology, Faculty of Medicine, Dalhousie University, Halifax NS B3H 4R2, Canada.
Biomacromolecules. 2025 Aug 11;26(8):4784-4811. doi: 10.1021/acs.biomac.5c00765. Epub 2025 Jul 15.
Degradable aliphatic polyesters (DAPs) are integral materials for the design of resorbable medical devices including resorbable sutures, drug delivery depots, and temporary tissue growth supports. The clinical application of DAPs is due to their ability to resorb over a therapeutic window. Control over resorption rates is defined by material properties, which inform the selection of a formulation for specific applications. This review examines the synthesis and degradation behavior of DAPs for biomedical applications. We focus on copolymer DAPs, which offer promising opportunities to tailor resorption by strategically incorporating diverse α,ω-dicarboxylic acid and α,ω-diol monomers. We analyze the molecular and macroscopic factors influencing hydrolytic degradation, correlating these to the copolymer composition. We highlight emerging approaches for assessing degradation behavior through efficient techniques and real-time monitoring capabilities. Material property-informed DAP innovation offers a strategy for improved resorbable device performance tailored for specific biomedical applications.
可降解脂肪族聚酯（DAPs）是可吸收医疗设备设计中不可或缺的材料，这些设备包括可吸收缝线、药物递送 depot 和临时组织生长支架。DAPs 的临床应用归因于它们在治疗窗口内能够吸收的能力。对吸收速率的控制由材料特性决定，这些特性为特定应用的配方选择提供依据。本综述考察了用于生物医学应用的 DAPs 的合成和降解行为。我们专注于共聚物 DAPs，通过策略性地引入不同的 α,ω-二羧酸和 α,ω-二醇单体，它们为定制吸收提供了有前景的机会。我们分析了影响水解降解的分子和宏观因素，并将这些因素与共聚物组成相关联。我们强调了通过高效技术和实时监测能力来评估降解行为的新兴方法。基于材料特性的 DAP 创新为改进针对特定生物医学应用定制的可吸收设备性能提供了一种策略。
