King Andrea, Ortiz Cynthia, Goswami Rachna, Kaufmann Tara L, Lee MinJae, Ibekwe-Agunanna Lynn, Sadeghi Navid, Yang Donghan M, Cowell Lindsay G, Hogan Timothy P, Wallner Lauren P, Mullins Megan A
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.
Department of Health Economics, Systems, and Policy, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Breast Cancer Res Treat. 2025 Jul 15. doi: 10.1007/s10549-025-07780-w.
BACKGROUND: Despite guideline recommendations, evidence suggests many women with metastatic breast cancer (mBC) do not receive specialty palliative care services despite high morbidity burden. Given the varied prognoses and disease trajectories of women with mBC, relatively little is known about palliative care delivery in this growing population, including timing and frequency of visits, location (inpatient vs. outpatient), and reasons for referral. METHODS: Using electronic health record and tumor registry data from a North Texas Comprehensive Cancer Center (2010-2023), we identified women who died with de novo or recurrent mBC. We examined receipt of palliative care (inpatient and outpatient), reasons for referral, and timing of palliative care encounters by duration of patient survival. We used multivariable logistic regression to assess associations between receipt of specialty palliative care and demographic, clinical, and survival characteristics. RESULTS: Among 265 women with mBC, 55.5% received no palliative care. Only women with short survival (< 18 months) received palliative care within 8 weeks of diagnosis. Most palliative care encounters were inpatient and occurred within ~ 1 month of death. In adjusted models, comorbidities and younger age were strongly associated with receiving outpatient palliative care. Most women were referred to palliative care for multiple reasons, with long-term survivors more likely to be referred for goals of care discussions alone. CONCLUSION: Palliative care for women with mBC is infrequent and often late, with referrals seemingly driven by the imminence of death rather than metastatic diagnosis. Strategies to better identify and triage specialty palliative care needs and make timely referrals are needed.
背景:尽管有指南建议,但有证据表明,许多转移性乳腺癌(mBC)女性患者尽管疾病负担高,但仍未接受专科姑息治疗服务。鉴于mBC女性患者的预后和疾病轨迹各不相同,对于这一不断增长的人群中姑息治疗的提供情况,包括就诊时间和频率、地点(住院与门诊)以及转诊原因,了解相对较少。 方法:利用北德克萨斯综合癌症中心(2010 - 2023年)的电子健康记录和肿瘤登记数据,我们确定了死于新发或复发性mBC的女性患者。我们研究了姑息治疗(住院和门诊)的接受情况、转诊原因以及根据患者生存时间的姑息治疗接触时机。我们使用多变量逻辑回归来评估接受专科姑息治疗与人口统计学、临床和生存特征之间的关联。 结果:在265例mBC女性患者中,55.5%未接受姑息治疗。只有生存时间短(<18个月)的女性患者在诊断后8周内接受了姑息治疗。大多数姑息治疗接触是住院治疗,且发生在死亡前约1个月内。在调整模型中,合并症和较年轻的年龄与接受门诊姑息治疗密切相关。大多数女性患者因多种原因被转诊至姑息治疗,长期生存者更有可能仅因护理目标讨论而被转诊。 结论:mBC女性患者的姑息治疗不常见且往往较晚,转诊似乎是由死亡临近而非转移性诊断驱动的。需要采取策略来更好地识别和分类专科姑息治疗需求并及时转诊。
Breast Cancer Res Treat. 2025-7-15
Health Technol Assess. 2006-9
Health Soc Care Deliv Res. 2025-7-16