Weiss D J, Raskin R, Zerbe C
J Am Vet Med Assoc. 1985 Nov 15;187(10):1038-40.
Two cases of myelodysplastic syndrome in the dog are described. Both cases were characterized by hepatomegaly, cytopenias, macrocytosis, cellular bone marrow, and dysplastic changes in all hematopoietic cell lines. Serum vitamin B12 and folic acid concentrations were within reference ranges in one dog, but vitamin B12 was slightly decreased in the other. Vitamin B12 therapy did not result in amelioration of the hematologic disorder. The duration of illness was approximately 5 months. Necropsy of one dog revealed an acute undifferentiated leukemia.
本文描述了两例犬骨髓增生异常综合征。两例均表现为肝肿大、血细胞减少、大细胞性贫血、骨髓细胞增多以及所有造血细胞系的发育异常改变。一只犬的血清维生素B12和叶酸浓度在参考范围内，但另一只犬的维生素B12略有降低。维生素B12治疗并未改善血液系统疾病。病程约5个月。对其中一只犬进行尸检发现为急性未分化白血病。
