Dantas Diego Bessa, Weber Vinicius Muller Reis, de Oliveira Bender Joyce Maria, Silva Anny Caroline, Diniz Larissa Severo Canha, Cavazzotto Timothy Gustavo, da Silva Danilo Fernandes, Queiroga Marcos Roberto
State University of Londrina, Celso Garcia Cid Highway, Pr 445 Km 380, University Campus, Postal Box 10.011, Londrina, PR, CEP 86.057-970, Brazil.
Central-West State University, Paraná, Brazil.
Clin Transl Oncol. 2025 Jul 15. doi: 10.1007/s12094-025-03983-1.
To evaluate the effects of aerobic exercise performed during chemotherapy infusion on symptom burden and quality of life in women with breast cancer.
This single-blind randomized controlled trial included 39 women with breast cancer undergoing chemotherapy at a specialized oncology hospital in Brazil. Participants were randomly assigned to an exercise group (n = 18) or control group (n = 21). The intervention group performed low-intensity aerobic cycling with a portable ergometer for 20 min during infusion sessions 2 through 6. Fatigue (Cancer Fatigue Scale) and quality of life (EORTC QLQ-C30) were assessed before the second and after the sixth infusion. Chemotherapy-related symptoms were also monitored via telephone recall 48-72 h post-infusion. Data were analyzed using GEE for symptom scores and repeated measures ANOVA for fatigue and quality of life outcomes.
Of the 51 breast cancer patients recruited, 39 completed the study. No significant baseline differences were found between the intervention (exercise) and control groups. There were no significant changes in quality of life or fatigue scores (EORTC-QLQ-C30 and CFS) over time between groups. However, the intervention group showed a significant reduction in the severity of alopecia between chemotherapy sessions, which was not observed in the control group.
While exercise during chemotherapy did not significantly impact overall quality of life or fatigue, it may help reduce the perceived severity of certain treatment-related symptoms such as alopecia.
评估化疗输液期间进行有氧运动对乳腺癌女性患者症状负担和生活质量的影响。
这项单盲随机对照试验纳入了巴西一家专业肿瘤医院39名正在接受化疗的乳腺癌女性患者。参与者被随机分配到运动组（n = 18）或对照组（n = 21）。干预组在第2至6次输液期间，使用便携式测力计进行20分钟的低强度有氧骑行。在第二次输液前和第六次输液后评估疲劳（癌症疲劳量表）和生活质量（欧洲癌症研究与治疗组织核心问卷QLQ-C30）。还通过输液后48 - 72小时的电话回访监测化疗相关症状。使用广义估计方程分析症状评分数据，使用重复测量方差分析疲劳和生活质量结果。
在招募的51名乳腺癌患者中，39名完成了研究。干预（运动）组和对照组之间未发现显著的基线差异。两组之间生活质量或疲劳评分（EORTC-QLQ-C30和CFS）随时间均无显著变化。然而，干预组在化疗疗程之间脱发严重程度显著降低，而对照组未观察到这一现象。
虽然化疗期间运动对总体生活质量或疲劳没有显著影响，但它可能有助于减轻某些与治疗相关症状（如脱发）的感知严重程度。
