Wagatsuma Kohei, Nojima Masanori, Matsumoto Takayuki, Matsuura Minoru, Iijima Hideki, Matsuoka Katsuyoshi, Ohmiya Naoki, Ishihara Shunji, Hirai Fumihito, Takeuchi Ken, Tamura Satoshi, Kinjo Fukunori, Ueno Nobuhiro, Naganuma Makoto, Watanabe Kenji, Moroi Rintaro, Nishimata Nobuaki, Motoya Satoshi, Kurahara Koichi, Takahashi Sakuma, Maemoto Atsuo, Hiraga Hiroto, Saruta Masayuki, Tominaga Keiichi, Hisabe Takashi, Tanaka Hiroki, Terai Shuji, Inokuchi Toshihiro, Takedomi Hironobu, Narimatsu Kazuyuki, Endo Katsuya, Nakamura Masanao, Hisamatsu Tadakazu, Nakase Hiroshi
Department of Gastroenterology and Hepatology Sapporo Medical University School of Medicine Sapporo Japan.
Center for Translational Research, The Institute of Medical Science, The University of Tokyo Minato-ku Japan.
JGH Open. 2025 Jul 14;9(7):e70209. doi: 10.1002/jgh3.70209. eCollection 2025 Jul.
The Japan COVID-19 Survey and the Questionnaire for Inflammatory Bowel Disease (J-DESIRE) identified multiple factors associated with anxiety regarding the novel coronavirus disease 2019 (COVID-19). However, no regional differences in anxiety were observed. In this post hoc analysis of J-DESIRE, we investigated the relationship between the municipal population size at the place of residence (MPSPR) and anxiety among patients with IBD in Japan during the COVID-19 pandemic.
We analyzed 2958 questionnaires collected from patients with IBD aged ≥ 16 years between March 2020 and June 2021. The primary endpoint was the association between the visual analogue scale (VAS) scores of anxiety and MPSPR during the COVID-19 pandemic. The mean VAS score for anxiety was higher than the overall mean VAS score in municipalities with large and small populations, while it was lower in municipalities with medium populations. Therefore, we categorized the population into three groups based on MPSPR: ≤ 150 000, 150 001-1 000 000, and ≥ 1 000 001. The three groups had different background factors, contents of anxiety, and sources of information regarding therapeutic drugs. These differences may have led to differences in the degree and content of anxiety.
We investigated the association between anxiety in Japanese patients with IBD and MPSPR nationwide during the COVID-19 pandemic in Japan. The results obtained in this analysis are useful not only in special situations such as the COVID-19 pandemic but also for considering regional differences in medical care.
日本新冠病毒疾病调查及炎症性肠病问卷（J-DESIRE）确定了与2019年新型冠状病毒病（COVID-19）焦虑相关的多个因素。然而，未观察到焦虑存在地区差异。在这项J-DESIRE的事后分析中，我们调查了COVID-19大流行期间日本炎症性肠病（IBD）患者居住地的市人口规模（MPSPR）与焦虑之间的关系。
我们分析了2020年3月至2021年6月期间从16岁及以上IBD患者收集的2958份问卷。主要终点是COVID-19大流行期间焦虑的视觉模拟量表（VAS）评分与MPSPR之间的关联。在人口多和少的市，焦虑的平均VAS评分高于总体平均VAS评分，而在人口中等的市则较低。因此，我们根据MPSPR将人口分为三组：≤150000、150001 - 1000000和≥1000001。这三组在背景因素、焦虑内容以及治疗药物的信息来源方面存在差异。这些差异可能导致了焦虑程度和内容的不同。
我们调查了日本COVID-19大流行期间全国IBD患者的焦虑与MPSPR之间的关联。该分析所得结果不仅在COVID-19大流行等特殊情况下有用，而且对于考虑医疗保健中的地区差异也有帮助。
