Streit Laura, Tanguy Emeline, Brunaud Laurent, Tóth Petra, Vitale Nicolas, Ory Stéphane, Gasman Stéphane
Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Département de Chirurgie Viscérale, Métabolique et Cancérologique (CVMC), INSERM NGERE-U1256, Université de Lorraine, CHRU Nancy, Hôpital Brabois adultes, Vandoeuvre-lès-Nancy, France.
Front Cell Dev Biol. 2025 Jul 1;13:1527083. doi: 10.3389/fcell.2025.1527083. eCollection 2025.
Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms arising from hormone-releasing cells. Secretion of hormones stored in vesicles occurs through calcium-regulated exocytosis, a process that needs to be tightly controlled to avoid unbalanced levels of hormones. A critical feature shared by most of the NETs is a dysfunctional secretory pathway mainly leading to hypersecretion, which often induces clinical complications. In this review, we focus on the cellular process of hormone exocytosis and discuss the potential molecular mechanisms leading to deregulated hormone secretion in various NETs. Particular attention is paid to expression level modifications for genes and proteins involved in the exocytic pathway in NETs.
神经内分泌肿瘤（NETs）是一组起源于激素释放细胞的异质性肿瘤。储存在囊泡中的激素通过钙调节的胞吐作用分泌，这一过程需要严格控制以避免激素水平失衡。大多数NETs共有的一个关键特征是分泌途径功能失调，主要导致分泌过多，这常常引发临床并发症。在本综述中，我们聚焦于激素胞吐的细胞过程，并讨论导致各种NETs中激素分泌失调的潜在分子机制。特别关注NETs中胞吐途径相关基因和蛋白质的表达水平变化。
