Stockbridge Melissa D, Venezia Jonathan H, Faria Andreia V, Bunker Lisa D, Durfee Alexandra Z, Kang Joseph, Neal Voss, Vitti Emilia, Fridriksson Julius, Hickok Gregory, Hillis Argye E
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
VA Loma Linda Healthcare System, Loma Linda, CA, 92357, USA.
Brain Netw Disord. 2025 Jun;1(2):98-108. doi: 10.1016/j.bnd.2024.08.001. Epub 2025 Feb 28.
Within the dual stream model for language, the bilateral dorsal superior temporal gyrus (STG) is associated with spectro-temporal analysis while the mid-post superior temporal sulcus is associated with processing of higher-level phonological codes. However, the true lateralization of functions needed for phonological discrimination at the word level remains unsettled. The aim of the present work was to determine if individuals with acute stroke primarily involving the left STG and middle temporal gyrus (MTG) demonstrated poorer discrimination (') between phonologically related words in a word-picture verification task than those with left hemisphere lesions outside the temporal lobe and compared to those with right hemisphere stroke. The latter would support a left bias and provide an estimate of the magnitude.
One hundred fourteen individuals with acute stroke completed both acute magnetic resonance imaging and a word-picture verification task with phonological and semantic foils. Eighty-nine participants had left hemisphere stroke (51 included the temporal lobe). Twenty participants had right hemisphere stroke (14 included the temporal lobe). Five participants with bilateral stroke were included (3 included the bilateral temporal lobes). Quantile regression was performed controlling for overall lesion volume, age, and sex.
While more than half of patients performed the task well, patients with left temporal lobe lesions were more likely to perform poorly.
These results confirm a role for the left superior temporal lobe, including the STG, in phonological processing during word recognition, and indicate that a subset of individuals (<50%) have varying degrees of left bias in discrimination of phonologically similar words in the STG.
在语言的双流模型中，双侧背侧颞上回（STG）与频谱 - 时间分析相关，而颞上沟中后部与更高级语音编码的处理相关。然而，单词层面语音辨别所需功能的真正侧化仍未确定。本研究的目的是确定主要累及左侧STG和颞中回（MTG）的急性中风患者在单词 - 图片验证任务中对语音相关单词的辨别能力是否比颞叶以外左侧半球病变的患者以及右侧半球中风的患者更差。后者将支持左侧偏向并提供其程度的估计。
114名急性中风患者完成了急性磁共振成像以及一项带有语音和语义陪衬的单词 - 图片验证任务。89名参与者为左侧半球中风（51名包括颞叶）。20名参与者为右侧半球中风（14名包括颞叶）。纳入5名双侧中风患者（3名包括双侧颞叶）。进行分位数回归，控制总体病变体积、年龄和性别。
虽然超过一半的患者任务完成良好，但左侧颞叶病变的患者更有可能表现不佳。
这些结果证实了左侧颞叶，包括STG，在单词识别过程中的语音处理中发挥作用，并表明一部分个体（<50%）在STG中对语音相似单词的辨别存在不同程度的左侧偏向。
